Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN1228684 (3S,5R)-2-(hydroxymethyl)-6- methoxy-oxane...

Synonyms: AC1L3MCP, AR-1J5791, AC1Q59HB, Methylglucoside, EINECS 246-894-8, ...

Bormans, G.M. et al., Rabito, C.A. et al., Kopsidas, G. et al.

Bormans, Van Oosterwyck, De Groot, Veyhl, Mortelmans, Verbruggen, Koepsell,

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High impact information on Methylglucoside

The tracer was found to be metabolically stable and did not accumulate in red blood cells, which indicates that methyl-D-glucoside is not transported by the sodium-independent transporter GLUT1 [1].
Autoradiography showed that methyl-D-glucoside was accumulated throughout the renal cortex, suggesting that both sodium-D-glucose cotransporters expressed in kidney, SGLT1 and SGLT2, are involved in the uptake [1].
In a further experiment, two glucose analogues (2'-deoxyglucose and methyl-D-glucoside) known to be actively transported into the cell but not metabolised past the first phosphorylation step were used [2].
The active transport of oc methyl-D-glucoside (oc MGP), a nonmetabolizable sugar, which shares the glucose-galactose transport system in kidney cells is mediated through a Na+-dependent, substrate-saturable process [3].

References

Synthesis and biologic evaluation of (11)c-methyl-d-glucoside, a tracer of the sodium-dependent glucose transporters. Bormans, G.M., Van Oosterwyck, G., De Groot, T.J., Veyhl, M., Mortelmans, L., Verbruggen, A.M., Koepsell, H. J. Nucl. Med. (2003) [Pubmed]
Mutagenesis by 9-aminoacridine in Salmonella typhimurium: inhibition by glucose and other PTS class A carbon sources. Kopsidas, G., MacPhee, D.G. Mutat. Res. (1994) [Pubmed]
Na+-dependent sugar transport in a cultured epithelial cell line from pig kidney. Rabito, C.A., Ausiello, D.A. J. Membr. Biol. (1980) [Pubmed]

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