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Chemical Compound Review:

Alanosine 2-amino-3-(hydroxy-nitroso- amino)propanoic...

Synonyms: DL-Alanosine, D,L-Alanosine, ALANOSINE, DL, CHEMBL24530, AG-G-07231, ...

Efferth, T. et al., Downs, S.M. et al., Kelley, J.M. et al.

Efferth, Miyachi, Drexler, Gebhart,

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Disease relevance of 5854-95-5

We conclude that ALA may be more suitable than MTX or TMX for MTAP-mediated chemoselective treatment of T-ALL [1].

High impact information on 5854-95-5

However, sodium hadacidin and dl-alanosine, inhibitors of adenylosuccinate synthetase, failed to elicit a maturational response in oocytes in vivo [2].
Thus, ALA could exhibit chemoselectivity in 9p21/MTAP-deleted cells, even if DHFR amplification occurs [1].
Organs in which DL-alanosine accumulates include the kidneys, lungs, liver, and small intestine [3].

References

Methylthioadenosine phosphorylase as target for chemoselective treatment of T-cell acute lymphoblastic leukemic cells. Efferth, T., Miyachi, H., Drexler, H.G., Gebhart, E. Blood Cells Mol. Dis. (2002) [Pubmed]
Induction of mouse oocyte maturation in vivo by perturbants of purine metabolism. Downs, S.M., Eppig, J.J. Biol. Reprod. (1987) [Pubmed]
Pharmacologic disposition of DL-alanosine in mice, rats, dogs, and monkeys. Kelley, J.M., Adamson, R.H., Cooney, D.A., Jayaram, H.N., Anandaraj, S. Cancer treatment reports. (1977) [Pubmed]

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