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Chemical Compound Review

AC1L3TLS     4-[[(2R,3S,4R)-5-(6- aminopurin-9-yl)-3,4...

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Disease relevance of Adenylosuccinic acid


High impact information on Adenylosuccinic acid


Chemical compound and disease context of Adenylosuccinic acid


Biological context of Adenylosuccinic acid


Anatomical context of Adenylosuccinic acid

  • The products of the two enzyme reactions, threo-beta-fluoro-SAICAR and threo-beta-fluoroadenylosuccinate, are inhibitors of adenylosuccinate lyase purified from rat skeletal muscle [16].
  • In order to determine whether this nucleobase transport system was bidirectional, mutant cell lines possessing this high affinity base transport capability were derived from a nucleoside transport-deficient derivative of an adenylosuccinate synthetase-deficient S49 cell line [17].
  • Earlier studies [J. Biol. Chem. 263:15354 (1988)] showed that anabolism of ddlno in human lymphoid cells is mediated via an initial step of phosphorylation and subsequent amination to dideoxy-AMP via adenylosuccinate synthetase/lyase [18].
  • These results show that the efficiency of PNC is about twice as high in the medulla cytosol as in the cortex cytosol, and that the activity of PNC in kidney is mainly limited by the activity of adenylosuccinate synthetase and supply of AMP [15].
  • In contrast, in type II fibroblasts, the activity with adenylosuccinate is only 3% of normal, whereas that with succinyl-AICAR is also 30% of normal [19].

Associations of Adenylosuccinic acid with other chemical compounds


Gene context of Adenylosuccinic acid


Analytical, diagnostic and therapeutic context of Adenylosuccinic acid


  1. Purine oversecretion in cultured murine lymphoma cells deficient in adenylosuccinate synthetase: genetic model for inherited hyperuricemia and gout. Ullman, B., Wormsted, M.A., Cohen, M.B., Martin, D.W. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  2. Nucleotide sequence and analysis of the purA gene encoding adenylosuccinate synthetase of Escherichia coli K12. Wolfe, S.A., Smith, J.M. J. Biol. Chem. (1988) [Pubmed]
  3. Three subunits contribute amino acids to the active site of tetrameric adenylosuccinate lyase: Lys268 and Glu275 are required. Brosius, J.L., Colman, R.F. Biochemistry (2002) [Pubmed]
  4. The purine nucleotide cycle in the regulation of ammoniagenesis during induction and cessation of chronic acidosis in the rat kidney. Bogusky, R.T., Steele, K.A., Lowenstein, L.M. Biochem. J. (1981) [Pubmed]
  5. Metabolic adaptation in phosphorylase kinase deficiency. Changes in metabolite concentrations during tetanic stimulation of mouse leg muscles. Rahim, Z.H., Perrett, D., Lutaya, G., Griffiths, J.R. Biochem. J. (1980) [Pubmed]
  6. Disruption of the purine nucleotide cycle by inhibition of adenylosuccinate lyase produces skeletal muscle dysfunction. Swain, J.L., Hines, J.J., Sabina, R.L., Harbury, O.L., Holmes, E.W. J. Clin. Invest. (1984) [Pubmed]
  7. An infantile autistic syndrome characterised by the presence of succinylpurines in body fluids. Jaeken, J., Van den Berghe, G. Lancet (1984) [Pubmed]
  8. Adenylosuccinate lyase of Bacillus subtilis regulates the activity of the glutamyl-tRNA synthetase. Gendron, N., Breton, R., Champagne, N., Lapointe, J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  9. Recombinant mouse muscle adenylosuccinate synthetase: overexpression, kinetics, and crystal structure. Iancu, C.V., Borza, T., Choe, J.Y., Fromm, H.J., Honzatko, R.B. J. Biol. Chem. (2001) [Pubmed]
  10. Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene. Xia, Y., McMillin, J.B., Lewis, A., Moore, M., Zhu, W.G., Williams, R.S., Kellems, R.E. J. Biol. Chem. (2000) [Pubmed]
  11. Synthesis and in vitro biological evaluation of N-[(5-amino-1-beta-D-ribofuranosyl-1H-imidazol-4-yl)carbonyl]-3- (hydroxynitrosamino)-L-alanine (L-alanosine AICO ribonucleoside). Strazzolini, P., Malabarba, A., Ferrari, P., Grandi, M., Cavalleri, B. J. Med. Chem. (1984) [Pubmed]
  12. Specificity of adenylosuccinate synthetase and adenylosuccinate lyase from Leishmania donovani. Selective amination of an antiprotozoal agent. Spector, T., Jones, T.E., Elion, G.B. J. Biol. Chem. (1979) [Pubmed]
  13. Anabolic pathway of 6-methoxypurine arabinoside in cells infected with varicella-zoster virus. de Miranda, P., Burnette, T.C., Biron, K.K., Miller, R.L., Averett, D.R., Krenitsky, T.A. Antimicrob. Agents Chemother. (1991) [Pubmed]
  14. Implication of His68 in the substrate site of Bacillus subtilis adenylosuccinate lyase by mutagenesis and affinity labeling with 2-[(4-bromo-2,3-dioxobutyl)thio]adenosine 5'-monophosphate. Lee, T.T., Worby, C., Bao, Z.Q., Dixon, J.E., Colman, R.F. Biochemistry (1998) [Pubmed]
  15. Purine nucleotide cycle in rat renal cortex and medulla under conditions that mimic normal and low oxygen supply. Stepinski, J., Pawelczyk, T., Bizon, D., Angielski, S. Kidney Int. (1996) [Pubmed]
  16. Metabolism of threo-beta-fluoroaspartate by H4 cells. Inhibition of adenylosuccinate lyase by fluoro analogs of its substrates. Casey, P.J., Abeles, R.H., Lowenstein, J.M. J. Biol. Chem. (1986) [Pubmed]
  17. Genetic demonstration of bidirectionality in the high affinity purine base transporter of mutant mouse S49 cells. Beck, J.T., Ullman, B. J. Biol. Chem. (1987) [Pubmed]
  18. Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells. Johnson, M.A., Fridland, A. Mol. Pharmacol. (1989) [Pubmed]
  19. Residual adenylosuccinase activities in fibroblasts of adenylosuccinase-deficient children: parallel deficiency with adenylosuccinate and succinyl-AICAR in profoundly retarded patients and non-parallel deficiency in a mildly retarded girl. Van den Bergh, F., Vincent, M.F., Jaeken, J., Van den Berghe, G. J. Inherit. Metab. Dis. (1993) [Pubmed]
  20. Amplification of an adenylosuccinate synthetase gene in alanosine-resistant murine T-lymphoma cells. Molecular cloning of a cDNA encoding the "non-muscle" isozyme. Guicherit, O.M., Cooper, B.F., Rudolph, F.B., Kellems, R.E. J. Biol. Chem. (1994) [Pubmed]
  21. Mechanism of the potentiating effect of ribavirin on the activity of 2',3'-dideoxyinosine against human immunodeficiency virus. Balzarini, J., Lee, C.K., Herdewijn, P., De Clercq, E. J. Biol. Chem. (1991) [Pubmed]
  22. Adenylosuccinate lyase from Artemia embryos. Purification and properties. Pinto, R.M., Faraldo, A., Fernández, A., Canales, J., Sillero, A., Sillero, M.A. J. Biol. Chem. (1983) [Pubmed]
  23. Adenylosuccinate synthetase: site of action of hydantocidin, a microbial phytotoxin. Siehl, D.L., Subramanian, M.V., Walters, E.W., Lee, S.F., Anderson, R.J., Toschi, A.G. Plant Physiol. (1996) [Pubmed]
  24. Implication of arginine-131 and arginine-303 in the substrate site of adenylosuccinate synthetase of Escherichia coli by affinity labeling with 6-(4-bromo-2,3-dioxobutyl)thioadenosine 5'-monophosphate. Lee, P., Gorrell, A., Fromm, H.J., Colman, R.F. Biochemistry (1999) [Pubmed]
  25. Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy. Marcé, S., Balagué, O., Colomo, L., Martinez, A., Höller, S., Villamor, N., Bosch, F., Ott, G., Rosenwald, A., Leoni, L., Esteller, M., Fraga, M.F., Montserrat, E., Colomer, D., Campo, E. Clin. Cancer Res. (2006) [Pubmed]
  26. A gene correcting the defect in the CHO mutant Ade -H, deficient in a branch point enzyme (adenylosuccinate synthetase) of de novo purine biosynthesis, is located on the long arm of chromosome 1. Lai, L.W., Hart, I.M., Patterson, D. Genomics (1991) [Pubmed]
  27. Identification of His141 in the active site of Bacillus subtilis adenylosuccinate lyase by affinity labeling with 6-(4-bromo-2,3-dioxobutyl)thioadenosine 5'-monophosphate. Lee, T.T., Worby, C., Dixon, J.E., Colman, R.F. J. Biol. Chem. (1997) [Pubmed]
  28. Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells. Sun, H., Li, N., Wang, X., Chen, T., Shi, L., Zhang, L., Wang, J., Wan, T., Cao, X. Mol. Cell. Biochem. (2005) [Pubmed]
  29. Unique kinetic mechanism of Plasmodium falciparum adenylosuccinate synthetase. Raman, J., Mehrotra, S., Anand, R.P., Balaram, H. Mol. Biochem. Parasitol. (2004) [Pubmed]
  30. His68 and His141 are critical contributors to the intersubunit catalytic site of adenylosuccinate lyase of Bacillus subtilis. Lee, T.T., Worby, C., Bao, Z.Q., Dixon, J.E., Colman, R.F. Biochemistry (1999) [Pubmed]
  31. High-performance liquid chromatography of proteins: purification of the acidic isozyme of adenylosuccinate synthetase from rat liver. Rudolph, F.B., Clark, S.W. Anal. Biochem. (1982) [Pubmed]
  32. Adenylosuccinate synthetase from Dictyostelium discoideum: effects of hadacidin analogs and binding of [14C]hadacidin. Jahngen, E.G., Rossomando, E.F. Arch. Biochem. Biophys. (1984) [Pubmed]
  33. Purification, crystallization, and properties of adenylosuccinate synthetase from rat skeletal muscle. Ogawa, H., Shiraki, H., Matsuda, Y., Kakiuchi, K., Nakagawa, H. J. Biochem. (1977) [Pubmed]
  34. Adenylosuccinate synthetase: recent developments. Honzatko, R.B., Stayton, M.M., Fromm, H.J. Adv. Enzymol. Relat. Areas Mol. Biol. (1999) [Pubmed]
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