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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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NAALADL1  -  N-acetylated alpha-linked acidic...

Homo sapiens

Synonyms: 100 kDa ileum brush border membrane protein, I100, Ileal dipeptidylpeptidase, N-acetylated-alpha-linked acidic dipeptidase-like protein, NAALADASEL, ...
 
 
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High impact information on NAALADL1

  • Here, we describe the cloning of human ileal 100-kDa protein, which we have called a NAALADase- "like" (NAALADase L) peptidase based on its sequence similarity to other members of this gene family, and its inability to hydrolyze NAAG in transient transfection experiments [1].
  • A novel 100-kDa ileal brush border membrane protein (I100) has been purified by anionic glycocholate affinity chromatography [2].
  • In the rat, the I100 protein is a 746-amino acid glycosylated (calculated core molecular mass of 80 kDa) type II integral membrane protein found on the apical surface of ileal villus enterocytes [2].
  • 4. We discovered key differences in the function and binding properties of guinea-pig and gorilla 5-HT1D receptors, and identified contributions of I100 and H102 of primate 5-HT1D receptors to isochroman binding [3].

References

  1. Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity. Pangalos, M.N., Neefs, J.M., Somers, M., Verhasselt, P., Bekkers, M., van der Helm, L., Fraiponts, E., Ashton, D., Gordon, R.D. J. Biol. Chem. (1999) [Pubmed]
  2. Cloning and characterization of a novel peptidase from rat and human ileum. Shneider, B.L., Thevananther, S., Moyer, M.S., Walters, H.C., Rinaldo, P., Devarajan, P., Sun, A.Q., Dawson, P.A., Ananthanarayanan, M. J. Biol. Chem. (1997) [Pubmed]
  3. Differential pharmacology between the guinea-pig and the gorilla 5-HT1D receptor as probed with isochromans (5-HT1D-selective ligands). Pregenzer, J.F., Alberts, G.L., Im, W.B., Slightom, J.L., Ennis, M.D., Hoffman, R.L., Ghazal, N.B., TenBrink, R.E. Br. J. Pharmacol. (1999) [Pubmed]
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