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Gene Review

SMC4  -  structural maintenance of chromosomes 4

Homo sapiens

Synonyms: CAP-C, CAPC, Chromosome-associated polypeptide C, SMC protein 4, SMC-4, ...
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High impact information on SMC4

  • Cells depleted of Ca2+ and Mg2+ showed partially decondensed chromosomes and a loss of Topo II and ScII, but not hCAP-C and histones [1].
  • The hCAP-C/hCAP-E complex is the human ortholog of the Xenopus chromosome-associated protein (XCAP)-C/XCAP-E complex required for mitotic chromosome condensation [2].

Other interactions of SMC4

  • Based on the sequence conservation and mitotic chromosome localization, hCAP-C-hCAP-E was determined to be the human ortholog of the Xenopus SMC complex, XCAP-C-XCAP-E [3].


  1. Cation-chromatin binding as shown by ion microscopy is essential for the structural integrity of chromosomes. Strick, R., Strissel, P.L., Gavrilov, K., Levi-Setti, R. J. Cell Biol. (2001) [Pubmed]
  2. Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics. Schmiesing, J.A., Ball, A.R., Gregson, H.C., Alderton, J.M., Zhou, S., Yokomori, K. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. Schmiesing, J.A., Gregson, H.C., Zhou, S., Yokomori, K. Mol. Cell. Biol. (2000) [Pubmed]
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