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Gene Review

SMC4  -  condensin subunit SMC4

Saccharomyces cerevisiae S288c

Synonyms: L9449.5, Structural maintenance of chromosomes protein 4, YLR086W
 
 
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High impact information on SMC4

  • Here we show that MIX-1 interacts with a mitotic condensin subunit, SMC-4, to achieve chromosome segregation [1].
  • SMC-4 and MIX-1 colocalize with centromere proteins on condensed mitotic chromosomes and are required for the restricted orientation of centromeres toward spindle poles [1].
  • Depletion of SMC-4/MIX-1 causes aberrant mitotic chromosome structure and segregation, but not dramatic decondensation at metaphase [1].
  • Cnd1, Cnd2, and Cnd3, three non-SMC subunits showing a high degree of sequence conservation to frog subunits, are essential for viability, and their gene disruption leads to a phenotype indistinguishable from that observed in cut3-477 and cut14-208, known mutations in SMC4 and SMC2-like subunits [2].
  • A role for Drosophila SMC4 in the resolution of sister chromatids in mitosis [3].
 

Biological context of SMC4

  • Both SMC2 and SMC4 are essential for chromosome transmission in anaphase [4].
  • Mitotic transmission of chromosome III carrying the rDNA translocation is impaired in smc2 and smc4 mutants [4].
  • In vivo localization of Smc4p fused to green fluorescent protein showed that, unexpectedly, in S. cerevisiae the condensin complex concentrates in the rDNA region at the G2/M phase of the cell cycle. rDNA segregation in mitosis is delayed and/or stalled in smc2 and smc4 mutants, compared with separation of pericentromeric and distal arm regions [4].
 

Other interactions of SMC4

References

  1. C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis. Hagstrom, K.A., Holmes, V.F., Cozzarelli, N.R., Meyer, B.J. Genes Dev. (2002) [Pubmed]
  2. Fission yeast condensin complex: essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4. Sutani, T., Yuasa, T., Tomonaga, T., Dohmae, N., Takio, K., Yanagida, M. Genes Dev. (1999) [Pubmed]
  3. A role for Drosophila SMC4 in the resolution of sister chromatids in mitosis. Steffensen, S., Coelho, P.A., Cobbe, N., Vass, S., Costa, M., Hassan, B., Prokopenko, S.N., Bellen, H., Heck, M.M., Sunkel, C.E. Curr. Biol. (2001) [Pubmed]
  4. The condensin complex governs chromosome condensation and mitotic transmission of rDNA. Freeman, L., Aragon-Alcaide, L., Strunnikov, A. J. Cell Biol. (2000) [Pubmed]
  5. Saccharomyces cerevisiae SMT4 encodes an evolutionarily conserved protease with a role in chromosome condensation regulation. Strunnikov, A.V., Aravind, L., Koonin, E.V. Genetics (2001) [Pubmed]
 
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