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Gene Review

cut3  -  condensin complex subunit Cut3

Schizosaccharomyces pombe 972h-

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Disease relevance of cut3


High impact information on cut3

  • Chromosome condensation requires condensin, which comprises five subunits [2].
  • A definitive defect of interphase is abolishment of Cds1 (a checkpoint kinase) activation in the presence of hydroxyurea in both cnd2-1 mutant cells and in cells where other condensin subunits have been genetically disrupted [2].
  • These results imply that condensin is not simply required for compaction, but plays a more complex role in chromosome architecture that is essential for mitotic and meiotic sister chromatid segregation [3].
  • To repress gene expression, MIX-1 acts in an X-chromosome complex that resembles the mitotic condensin complex yet lacks chromosome segregation function [3].
  • Condensin subunits tagged with GFP were observed to alter dramatically their localization during the cell cycle, enriched in the nucleus during mitosis, but cytoplasmic during other stages [4].

Biological context of cut3


Anatomical context of cut3


Other interactions of cut3


Analytical, diagnostic and therapeutic context of cut3


  1. Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior. Bhalla, N., Biggins, S., Murray, A.W. Mol. Biol. Cell (2002) [Pubmed]
  2. Cnd2 has dual roles in mitotic condensation and interphase. Aono, N., Sutani, T., Tomonaga, T., Mochida, S., Yanagida, M. Nature (2002) [Pubmed]
  3. C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis. Hagstrom, K.A., Holmes, V.F., Cozzarelli, N.R., Meyer, B.J. Genes Dev. (2002) [Pubmed]
  4. Fission yeast condensin complex: essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4. Sutani, T., Yuasa, T., Tomonaga, T., Dohmae, N., Takio, K., Yanagida, M. Genes Dev. (1999) [Pubmed]
  5. Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis. Saka, Y., Sutani, T., Yamashita, Y., Saitoh, S., Takeuchi, M., Nakaseko, Y., Yanagida, M. EMBO J. (1994) [Pubmed]
  6. Cti1/C1D interacts with condensin SMC hinge and supports the DNA repair function of condensin. Chen, E.S., Sutani, T., Yanagida, M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  7. Brc1-mediated DNA repair and damage tolerance. Sheedy, D.M., Dimitrova, D., Rankin, J.K., Bass, K.L., Lee, K.M., Tapia-Alveal, C., Harvey, S.H., Murray, J.M., O'Connell, M.J. Genetics (2005) [Pubmed]
  8. S. pombe aurora kinase/survivin is required for chromosome condensation and the spindle checkpoint attachment response. Petersen, J., Hagan, I.M. Curr. Biol. (2003) [Pubmed]
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