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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ARPC3  -  actin related protein 2/3 complex, subunit...

Homo sapiens

Synonyms: ARC21, Actin-related protein 2/3 complex subunit 3, Arp2/3 complex 21 kDa subunit, p21-ARC, p21-Arc
 
 
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Disease relevance of ARPC3

 

High impact information on ARPC3

  • ARPC3 p21 and ARPC5 p16 are globular alpha-helical subunits [2].
  • In patient ARC-21, a methionine-to-threonine substitution at position 1772 in the factor VIII light chain creates a potential new N-glycosylation site at asparagine-1770 [3].
  • The combined data suggest that the extreme C-terminus of the A region and the C-terminus of the C region of N-WASP are proximal to ARPC3 [4].
  • CONCLUSION: Both SSH1 and ARPC3 are involved in the actin cytoskeleton pathway and interacted with adherent junctions in the epidermal cells [5].

References

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. Welch, M.D., DePace, A.H., Verma, S., Iwamatsu, A., Mitchison, T.J. J. Cell Biol. (1997) [Pubmed]
  2. Crystal structure of Arp2/3 complex. Robinson, R.C., Turbedsky, K., Kaiser, D.A., Marchand, J.B., Higgs, H.N., Choe, S., Pollard, T.D. Science (2001) [Pubmed]
  3. Hemophilia A due to mutations that create new N-glycosylation sites. Aly, A.M., Higuchi, M., Kasper, C.K., Kazazian, H.H., Antonarakis, S.E., Hoyer, L.W. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. NMR analyses of the activation of the Arp2/3 complex by neuronal Wiskott-Aldrich syndrome protein. Kreishman-Deitrick, M., Goley, E.D., Burdine, L., Denison, C., Egile, C., Li, R., Murali, N., Kodadek, T.J., Welch, M.D., Rosen, M.K. Biochemistry (2005) [Pubmed]
  5. Two closely linked variations in actin cytoskeleton pathway in a Chinese pedigree with disseminated superficial actinic porokeratosis. Zhang, Z.H., Huang, W., Niu, Z.M., Liu, W.D., Xiang, L.H., Yuan, W.T., Zhao, J.J., Gu, C.Y., Chai, B., Jiang, F.X., Zhang, J., Xu, S.J., Zheng, Z.Z. J. Am. Acad. Dermatol. (2005) [Pubmed]
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