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Gene Review

KCNMB2  -  potassium channel subfamily M regulatory...

Homo sapiens

Synonyms: BK channel subunit beta-2, BKbeta2, Calcium-activated potassium channel subunit beta-2, Calcium-activated potassium channel, subfamily M subunit beta-2, Charybdotoxin receptor subunit beta-2, ...
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Disease relevance of KCNMB2

  • Coupling constant information has allowed the determination of chi(1) and chi(2) torsion angles, backbone phi angles, as well as 43 of 81 possible assignments to H beta 2/beta 3 pairs [1].

High impact information on KCNMB2

  • HM40 was the predominant, accounting for 84.7-98.7% of all tubulin; expression of the other four isotypes (Hbeta9, Hbeta4, H5beta, and Hbeta2) was also detected but at lower levels [2].
  • In contrast, P beta chain of H alpha 2 P beta 2 hybrid is refractory to exchange with H beta chain at pH 7.0 as well as at pH 6.0, suggesting that the stability of H alpha 2 P beta 2 is higher compared to that of HbA (H alpha 2 H beta 2) [3].
  • The gene for the human H beta 3 was specifically localized on chromosome 12q13 [4].
  • The H beta 3 mRNA is expressed mostly in brain, smooth muscle and ovary [4].
  • The cloned H beta 3 subunit was further expressed in Xenopus oocytes to demonstrate its ability to modulate VDCC activity [4].

Other interactions of KCNMB2

  • Other proton interactions were tentatively assigned to H beta 1 of His-44, H delta 2 of His-46 and to H beta 2 of His-44 [5].


  1. Detailed NMR analysis of the heme-protein interactions in component IV Glycera dibranchiata monomeric hemoglobin-CO. Alam, S.L., Volkman, B.F., Markley, J.L., Satterlee, J.D. J. Biomol. NMR (1998) [Pubmed]
  2. Expression of beta-tubulin isotypes in human ovarian carcinoma xenografts and in a sub-panel of human cancer cell lines from the NCI-Anticancer Drug Screen: correlation with sensitivity to microtubule active agents. Nicoletti, M.I., Valoti, G., Giannakakou, P., Zhan, Z., Kim, J.H., Lucchini, V., Landoni, F., Mayo, J.G., Giavazzi, R., Fojo, T. Clin. Cancer Res. (2001) [Pubmed]
  3. Chimeric hemoglobins--hybrids of human and swine hemoglobin: assembly and stability of interspecies hybrids. Rao, M.J., Manjula, B.N., Kumar, R., Acharya, A.S. Protein Sci. (1996) [Pubmed]
  4. Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit. Collin, T., Lory, P., Taviaux, S., Courtieu, C., Guilbault, P., Berta, P., Nargeot, J. Eur. J. Biochem. (1994) [Pubmed]
  5. An ENDOR study of human and bovine erythrocyte superoxide dismutase: 1H and 14N interactions. Hüttermann, J., Kappl, R., Banci, L., Bertini, I. Biochim. Biophys. Acta (1988) [Pubmed]
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