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Gene Review:

ldh - L-lactate dehydrogenase

Streptococcus mutans UA159

Asanuma, N. et al., Hillman, J.D. et al., Merritt, J. et al., Yamada, T. et al.

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Disease relevance of ldh

Recombinant DNA methods were used to make the Streptococcus mutans supercolonizing strain, JH1140, lactate dehydrogenase deficient by deleting virtually all of the ldh open reading frame (ORF) [1].

High impact information on ldh

On the contrary, ldh mRNA increased when excess glucose was supplied and the growth rate was high [2].
The amount of pfl mRNA in cells was lower at pH 4.5 than pH 6.9, whereas the level of ldh mRNA was higher at pH 4 [2].
We placed the luciferase gene under the control of the S. mutans lactate dehydrogenase promoter (ldh) and integrated the construct onto its native position on the chromosome [3].
A fructose 1,6-diphosphate-independent L-lactate dehydrogenase in a strain of Streptococcus mutans [4].

References

Construction and characterization of an effector strain of Streptococcus mutans for replacement therapy of dental caries. Hillman, J.D., Brooks, T.A., Michalek, S.M., Harmon, C.C., Snoep, J.L., van Der Weijden, C.C. Infect. Immun. (2000) [Pubmed]
Structure and transcriptional regulation of the gene encoding pyruvate formate-lyase of a ruminal bacterium, Streptococcus bovis. Asanuma, N., Iwamoto, M., Hino, T. Microbiology (Reading, Engl.) (1999) [Pubmed]
Non-disruptive, real-time analyses of the metabolic status and viability of Streptococcus mutans cells in response to antimicrobial treatments. Merritt, J., Kreth, J., Qi, F., Sullivan, R., Shi, W. J. Microbiol. Methods (2005) [Pubmed]
A fructose 1,6-diphosphate-independent L-lactate dehydrogenase in a strain of Streptococcus mutans. Yamada, T., Endo, K., Araya, S. Arch. Oral Biol. (1976) [Pubmed]

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