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Gene Review:

lacA - galactose-6-phosphate isomerase subunit LacA

Streptococcus mutans UA159

Jagusztyn-Krynicka, E.K. et al., Abranches, J. et al.

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Disease relevance of lacA

DNA cloned into Escherichia coli K-12 from a serotype c strain of Streptococcus mutans encodes three enzyme activities for galactose utilization via the tagatose 6-phosphate pathway: galactose 6-phosphate isomerase, tagatose 6-phosphate kinase, and tagatose-1,6-bisphosphate aldolase [1].

High impact information on lacA

Mutation of the lacA gene of the tagatose pathway caused impaired growth in lactose and galactose, suggesting that galactose can only be efficiently utilized when both the Leloir and tagatose pathways are functional [2].

References

Streptococcus mutans serotype c tagatose 6-phosphate pathway gene cluster. Jagusztyn-Krynicka, E.K., Hansen, J.B., Crow, V.L., Thomas, T.D., Honeyman, A.L., Curtiss, R. J. Bacteriol. (1992) [Pubmed]
Galactose metabolism by Streptococcus mutans. Abranches, J., Chen, Y.Y., Burne, R.A. Appl. Environ. Microbiol. (2004) [Pubmed]

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