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Chemical Compound Review

NSC-57553     [2,3,4-trihydroxy-5- (phosphonooxymethyl)ox...

Synonyms: KST-1B4651, AC1Q6SXN, NSC57553, AR-1B8318, AC1L19V8, ...
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Disease relevance of FRUCTOSE-16-DIPHOSPHATE


High impact information on FRUCTOSE-16-DIPHOSPHATE

  • In addition to CcpA, carbon catabolite activation of the pta gene therefore requires at least two other cofactors, FBP and either HPr or Crh, phosphorylated at Ser-46 by the ATP-dependent Hpr kinase [6].
  • Restriction endonuclease mapping of pPC37 and pPC58 and DNA hybridization studies indicated that a 2.1-kb region of these two clones of C. acetobutylicum DNA encodes the FDP-activated LDH [7].
  • Tagatose-1,6-bisphosphate aldolase (EC is situated at the branching of the tagatose-6-phosphate and Embden-Meyerhof-Parnas (glycolysis) metabolic pathways, where it catalyzes the reversible cleavage of tagatose-1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde 3-phosphate [3].
  • The H. influenzae glycerol kinase is inhibited by FBP but not by IIA(Glc), in agreement with the prediction based on sequence comparison [8].
  • The enzyme from Escherichia coli is an allosteric regulatory enzyme whose activity is inhibited by fructose 1,6-bisphosphate (FBP) and the glucose-specific phosphocarrier of the phosphoenolpyruvate:glycose phosphotransferase system, IIA(Glc) (previously termed III(Glc)) [8].

Biological context of FRUCTOSE-16-DIPHOSPHATE


Anatomical context of FRUCTOSE-16-DIPHOSPHATE


Associations of FRUCTOSE-16-DIPHOSPHATE with other chemical compounds


Analytical, diagnostic and therapeutic context of FRUCTOSE-16-DIPHOSPHATE


  1. Characterization of chimeric ADPglucose pyrophosphorylases of Escherichia coli and Agrobacterium tumefaciens. Importance of the C-terminus on the selectivity for allosteric regulators. Ballicora, M.A., Sesma, J.I., Iglesias, A.A., Preiss, J. Biochemistry (2002) [Pubmed]
  2. Immunological study of lactate dehydrogenase from Streptococcus mutans and evidence of common antigenic domains with lactate dehydrogenases from lactic bacteria. Sommer, P., Klein, J.P., Ogier, J.A., Frank, R.M. Infect. Immun. (1986) [Pubmed]
  3. Purification, crystallization and preliminary X-ray analysis of native and selenomethionine class I tagatose-1,6-bisphosphate aldolase from Streptococcus pyogenes. Liotard, B., Sygusch, J. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  4. Studies on the allosteric nature of acetate kinase from Bacillus stearothermophilus. Nakajima, H., Suzuki, K., Imahori, K. J. Biochem. (1979) [Pubmed]
  5. Cloning and expression of the Clostridium thermocellum L-lactate dehydrogenase gene in Escherichia coli and enzyme characterization. Ozkan, M., Yilmaz, E.I., Lynd, L.R., Ozcengiz, G. Can. J. Microbiol. (2004) [Pubmed]
  6. Catabolite regulation of the pta gene as part of carbon flow pathways in Bacillus subtilis. Presecan-Siedel, E., Galinier, A., Longin, R., Deutscher, J., Danchin, A., Glaser, P., Martin-Verstraete, I. J. Bacteriol. (1999) [Pubmed]
  7. Cloning of a lactate dehydrogenase gene from Clostridium acetobutylicum B643 and expression in Escherichia coli. Contag, P.R., Williams, M.G., Rogers, P. Appl. Environ. Microbiol. (1990) [Pubmed]
  8. Subcloning, expression, purification, and characterization of Haemophilus influenzae glycerol kinase. Pawlyk, A.C., Pettigrew, D.W. Protein Expr. Purif. (2001) [Pubmed]
  9. 2,5-Dimethyl-4-hydroxy-3(2H)-furanone as a secondary metabolite from D-fructose-1,6-diphosphate metabolism by Zygosaccharomyces rouxii. Dahlen, T., Hauck, T., Wein, M., Schwab, W. J. Biosci. Bioeng. (2001) [Pubmed]
  10. Sodium d-fructose-1,6-diphosphate vs. sodium monohydrogen phosphate in total parenteral nutrition: a comparative in vitro assessment of calcium phosphate compatibility. Prinzivalli, M., Ceccarelli, S. JPEN. Journal of parenteral and enteral nutrition. (1999) [Pubmed]
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