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APC2  -  adenomatosis polyposis coli 2

Homo sapiens

Synonyms: APC-like, APCL, Adenomatous polyposis coli protein 2, Adenomatous polyposis coli protein-like
 
 
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High impact information on APC2

  • Like APC, APC2 regulates the formation of active betacatenin-Tcf complexes, as demonstrated using transient transcriptional activation assays in APC -/- colon carcinoma cells [1].
  • Tumour cell lines stably transfected with LEF1(DN) or APC2, or transiently transfected with short-interfering RNA (siRNA) against beta-catenin showed a significant downregulation of ascl2 [2].
  • This assay has been validated in a 96-well plate format and successfully implemented to identify novel small molecule compounds that potently inhibit APC2/APC11 ligase activity [3].
  • METHODS: Data of 215 patients treated with a high power argon plasma coagulation system in the upper gastrointestinal tract 04/2003-01/2004, using a VIO APC device (VIO 300 D with APC 2; Erbe Elektromedizin, Tübingen, Germany; pulsed argon plasma coagulation, 20-120W), were reviewed and analyzed [4].

References

  1. Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. van Es, J.H., Kirkpatrick, C., van de Wetering, M., Molenaar, M., Miles, A., Kuipers, J., Destrée, O., Peifer, M., Clevers, H. Curr. Biol. (1999) [Pubmed]
  2. Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia. Jubb, A.M., Chalasani, S., Frantz, G.D., Smits, R., Grabsch, H.I., Kavi, V., Maughan, N.J., Hillan, K.J., Quirke, P., Koeppen, H. Oncogene (2006) [Pubmed]
  3. High-Throughput Screening for Inhibitors of the E3 Ubiquitin Ligase APC. Huang, J., Sheung, J., Dong, G., Coquilla, C., Daniel-Issakani, S., Payan, D.G. Meth. Enzymol. (2005) [Pubmed]
  4. Safety and efficacy of a new high power argon plasma coagulation system (hp-APC) in lesions of the upper gastrointestinal tract. Manner, H., May, A., Faerber, M., Rabenstein, T., Ell, C. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. (2006) [Pubmed]
 
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