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Gene Review

ASCL2  -  achaete-scute family bHLH transcription...

Homo sapiens

Synonyms: ASH-2, ASH2, Achaete-scute homolog 2, BHLHA45, Class A basic helix-loop-helix protein 45, ...
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Disease relevance of ASCL2


Psychiatry related information on ASCL2

  • The data suggest that a complex interplay of activators (Hash-2, HEB) and repressors (Stra13, I-mfa) could be involved in extravillous trophoblast differentiation whereas downregulation of Id proteins could play a role in syncytialisation [5].

High impact information on ASCL2


Biological context of ASCL2


Anatomical context of ASCL2


Associations of ASCL2 with chemical compounds


Regulatory relationships of ASCL2

  • The expression of proprotein convertase PACE4 is highly regulated by Hash-2 in placenta: possible role of placenta-specific basic helix-loop-helix transcription factor, human achaete-scute homologue-2 [12].
  • These findings suggest that Mash-2 may serve as a hypoxia-induced transcription factor that prevents differentiation to syncytiotrophoblast and aromatase induction in human trophoblast cultured under low O2 conditions [4].

Other interactions of ASCL2


Analytical, diagnostic and therapeutic context of ASCL2


  1. The human ASCL2 gene escaping genomic imprinting and its expression pattern. Miyamoto, T., Hasuike, S., Jinno, Y., Soejima, H., Yun, K., Miura, K., Ishikawa, M., Niikawa, N. J. Assist. Reprod. Genet. (2002) [Pubmed]
  2. USF1 and USF2 mediate inhibition of human trophoblast differentiation and CYP19 gene expression by Mash-2 and hypoxia. Jiang, B., Mendelson, C.R. Mol. Cell. Biol. (2003) [Pubmed]
  3. Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia. Jubb, A.M., Chalasani, S., Frantz, G.D., Smits, R., Grabsch, H.I., Kavi, V., Maughan, N.J., Hillan, K.J., Quirke, P., Koeppen, H. Oncogene (2006) [Pubmed]
  4. Hypoxia prevents induction of aromatase expression in human trophoblast cells in culture: potential inhibitory role of the hypoxia-inducible transcription factor Mash-2 (mammalian achaete-scute homologous protein-2). Jiang, B., Kamat, A., Mendelson, C.R. Mol. Endocrinol. (2000) [Pubmed]
  5. Tissue-specific and ubiquitous basic helix-loop-helix transcription factors in human placental trophoblasts. Meinhardt, G., Husslein, P., Knöfler, M. Placenta (2005) [Pubmed]
  6. O2 enhancement of human trophoblast differentiation and hCYP19 (aromatase) gene expression are mediated by proteasomal degradation of USF1 and USF2. Jiang, B., Mendelson, C.R. Mol. Cell. Biol. (2005) [Pubmed]
  7. JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). Zhang, D., Yoon, H.G., Wong, J. Mol. Cell. Biol. (2005) [Pubmed]
  8. The Human Achaete Scute Homolog 2 gene contains two promotors, generating overlapping transcripts and encoding two proteins with different nuclear localization. Westerman, B.A., Poutsma, A., Looijenga, L.H., Wouters, D., van Wijk, I.J., Oudejans, C.B. Placenta (2001) [Pubmed]
  9. Characterization of the Placenta Specific Bovine Mammalian Achaete Scute-like Homologue 2 (Mash2) Gene. Arnold, D.R., Lefebvre, R., Smith, L.C. Placenta (2006) [Pubmed]
  10. Developmental and evolutionary aspects of the basic helix-loop-helix transcription factors Atonal-like 1 and Achaete-scute homolog 2 in the jellyfish. Seipel, K., Yanze, N., Schmid, V. Dev. Biol. (2004) [Pubmed]
  11. A repertoire of differentially expressed transcription factors that offers insight into mechanisms of human cytotrophoblast differentiation. Janatpour, M.J., Utset, M.F., Cross, J.C., Rossant, J., Dong, J., Israel, M.A., Fisher, S.J. Dev. Genet. (1999) [Pubmed]
  12. The expression of proprotein convertase PACE4 is highly regulated by Hash-2 in placenta: possible role of placenta-specific basic helix-loop-helix transcription factor, human achaete-scute homologue-2. Koide, S., Yoshida, I., Tsuji, A., Matsuda, Y. J. Biochem. (2003) [Pubmed]
  13. To proliferate or to divide - to be or not to be. Genbacev, O. Early pregnancy (Online) (2001) [Pubmed]
  14. Genomic cloning and localization to chromosome 11p15.5 of the human achaete-scute homolog 2 (ASCL2). Miyamoto, T., Jinno, Y., Sasaki, T., Ikeda, Y., Masuzaki, H., Niikawa, N., Ishikawa, M. Cytogenet. Cell Genet. (1996) [Pubmed]
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