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Gene Review:

sloA - iron ABC transporter ATP-binding protein

Streptococcus mutans UA159

Paik, S. et al., Kitten, T. et al.

Kitten, Munro, Michalek, Macrina,

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Disease relevance of sloA

Finally, a sloA mutant demonstrated loss of virulence in a rat model of endocarditis, suggesting that metal transport is required for endocarditis pathogenesis [1].

High impact information on sloA

As with other LraI operons, the sloA and sloB genes apparently encode components of an ATP-binding cassette transport system [2].
Fe at 10 micro M supported growth of the wild-type strain but not of a sloA or sloC mutant [1].

References

The sloABCR operon of Streptococcus mutans encodes an Mn and Fe transport system required for endocarditis virulence and its Mn-dependent repressor. Paik, S., Brown, A., Munro, C.L., Cornelissen, C.N., Kitten, T. J. Bacteriol. (2003) [Pubmed]
Genetic characterization of a Streptococcus mutans LraI family operon and role in virulence. Kitten, T., Munro, C.L., Michalek, S.M., Macrina, F.L. Infect. Immun. (2000) [Pubmed]

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