Disease relevance of sloC

• The sloC mutant was indistinguishable from its wild-type parent in a gnotobiotic rat model of caries but was significantly less virulent in a rat model of endocarditis [1].

High impact information on sloC

• We have identified and characterized the chromosomal locus containing the LraI family gene (designated sloC) from Streptococcus mutans, an agent of dental caries and endocarditis in humans [1].
• Mutagenesis of sloC in S. mutans resulted in apparent loss of expression of the entire operon as assessed by Northern blot analysis [1].
• Fe at 10 micro M supported growth of the wild-type strain but not of a sloA or sloC mutant [2].
• Mn at 0.1 micro M supported growth of the wild-type strain and sloR mutant but not of sloA or sloC mutants [2].

Analytical, diagnostic and therapeutic context of sloC

• Northern blot analysis indicated that sloC is cotranscribed with three other genes [1].

References