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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

sloR  -  metal-dependent transcriptional regulator

Streptococcus mutans UA159

 
 
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Disease relevance of sloR

  • The product of the fourth gene, sloR, has homology to the metal-dependent regulator from Corynebacterium diphtheriae, DtxR [1].
 

High impact information on sloR

  • Specifically, the results of gel mobility shift assays revealed the sloABC, sloR, comDE, ropA, sod, and spaP promoters as targets of SloR binding [2].
  • Mn at 0.1 micro M supported growth of the wild-type strain and sloR mutant but not of sloA or sloC mutants [3].
 

Analytical, diagnostic and therapeutic context of sloR

  • By Western blotting, addition of Mn to the growth medium repressed SloC expression in a wild-type strain but not in a sloR mutant [3].

References

  1. Genetic characterization of a Streptococcus mutans LraI family operon and role in virulence. Kitten, T., Munro, C.L., Michalek, S.M., Macrina, F.L. Infect. Immun. (2000) [Pubmed]
  2. The SloR/Dlg metalloregulator modulates Streptococcus mutans virulence gene expression. Rolerson, E., Swick, A., Newlon, L., Palmer, C., Pan, Y., Keeshan, B., Spatafora, G. J. Bacteriol. (2006) [Pubmed]
  3. The sloABCR operon of Streptococcus mutans encodes an Mn and Fe transport system required for endocarditis virulence and its Mn-dependent repressor. Paik, S., Brown, A., Munro, C.L., Cornelissen, C.N., Kitten, T. J. Bacteriol. (2003) [Pubmed]
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