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Gene Review

ABCA8  -  ATP-binding cassette, sub-family A (ABC1),...

Homo sapiens

Synonyms: ATP-binding cassette sub-family A member 8, KIAA0822
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High impact information on ABCA8

  • Although ABCA7 and ABCA8 expression was relatively low in all cells, the highest expression occurred in microglia and neurons, respectively [1].
  • We examined the transport capacity in Xenopus laevis oocytes of human EST KIAA0822/ABCA8, a member of the ABC superfamily [2].
  • The deduced mouse ABCA8a protein is 66% identical with that of human ABCA8 and possesses features common to the ABC superfamily [3].
  • The results suggest that ABCA8 may play a role in digoxin metabolism in the liver [3].

Analytical, diagnostic and therapeutic context of ABCA8

  • We further evaluated the effect of acute digoxin (a substrate for ABCA8) intoxication on the mRNA expression of ABCA8 using northern blotting with a 3' non-coding region as a probe to avoid cross-hybridization with other ABCA genes [3].


  1. Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells. Kim, W.S., Guillemin, G.J., Glaros, E.N., Lim, C.K., Garner, B. Neuroreport (2006) [Pubmed]
  2. Functional analysis of ABCA8, a new drug transporter. Tsuruoka, S., Ishibashi, K., Yamamoto, H., Wakaumi, M., Suzuki, M., Schwartz, G.J., Imai, M., Fujimura, A. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  3. Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver. Wakaumi, M., Ishibashi, K., Ando, H., Kasanuki, H., Tsuruoka, S. Clin. Exp. Pharmacol. Physiol. (2005) [Pubmed]
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