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Gene Review:

pyrF - OMP decarboxylase; OMPDCase; OMPdecase

Escherichia coli CFT073

Sander, P. et al., Velayos, A. et al., Gillum, A.M. et al.

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Disease relevance of pyrF

Here we describe a vector-host system for gene replacement in mycobacteria, the utility of which was investigated using functional inactivation of the pyrF gene in Mycobacterium smegmatis as a model [1].
Both plasmids also complemented the corresponding OMPdecase mutation (pyrF) in E. coli [2].

High impact information on pyrF

Interallelic complementation at the pyrF locus and the homodimeric nature of orotate phosphoribosyltransferase (OPRTase) in Mucor circinelloides [3].

References

rpsL+: a dominant selectable marker for gene replacement in mycobacteria. Sander, P., Meier, A., Böttger, E.C. Mol. Microbiol. (1995) [Pubmed]
Isolation of the Candida albicans gene for orotidine-5'-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Gillum, A.M., Tsay, E.Y., Kirsch, D.R. Mol. Gen. Genet. (1984) [Pubmed]
Interallelic complementation at the pyrF locus and the homodimeric nature of orotate phosphoribosyltransferase (OPRTase) in Mucor circinelloides. Velayos, A., Alvarez, M.I., Eslava, A.P., Iturriaga, E.A. Mol. Gen. Genet. (1998) [Pubmed]

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