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Gene Review

pyrE  -  orotate phosphoribosyltransferase

Escherichia coli UTI89

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Disease relevance of pyrE

  • A Thermus thermophilus host strain of which the leuB gene was totally deleted was constructed from a delta pyrE strain by a two step method [1].
  • Effect of UTP and GTP pools on attenuation at the pyrE gene of Escherichia coli [2].

High impact information on pyrE

  • The multifunctional protein uridine 5'-monophosphate (UMP) synthase catalyzes the final two reactions of the de novo biosynthesis of UMP in mammalian cells by the sequential action of orotate phosphoribosyltransferase (EC and orotidine 5'-monophosphate (OMP) decarboxylase (EC [3].
  • Second, the inserted pyrE gene was deleted by using 5-fluoroorotic acid [1].
  • These results suggest that the gene replacement deletion method using the pyrE gene is useful for the construction of a reliable plasmid vector system and it can be applied to the selection of stabilized enzymes [1].

Analytical, diagnostic and therapeutic context of pyrE


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