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Gene Review:

c2511 - transposase/IS protein

Escherichia coli CFT073

Mendiola, M.V. et al., Derbyshire, K.M. et al., Berg, C.M. et al.

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Disease relevance of c2511

In addition, the native transposase is stabilized in lon- strains of Escherichia coli, and, in these protease-deficient strains, trans action of transposase is increased 10- to 100-fold [1].
Such P1::Tn5 specialized transducing phage are not found when a mutant Tn5 element lacking a functional transposase is employed [2].

High impact information on c2511

This model also draws support from the finding that the IS91 transposase is related in sequence to the superfamily of rolling-circle replication proteins and the observation that IRR shows some conservation in sequence and secondary structure with the origins of replication of some rolling-circle replication plasmids [3].

References

Role of instability in the cis action of the insertion sequence IS903 transposase. Derbyshire, K.M., Kramer, M., Grindley, N.D. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
Transductional instability of Tn5-induced mutations: generalized and specialized transduction of Tn5 by bacteriophage P1. Berg, C.M., Grullón, C.A., Wang, A., Whalen, W.A., Berg, D.E. Genetics (1983) [Pubmed]
Differential roles of the transposon termini in IS91 transposition. Mendiola, M.V., Bernales, I., de la Cruz, F. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]

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