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Gene Review

gshA  -  glutamate--cysteine ligase

Escherichia coli CFT073

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High impact information on gshA

  • Gamma-glutamylcysteine synthetase (gamma-GCS, glutamate-cysteine ligase), which catalyzes the first and rate-limiting step in glutathione biosynthesis, is present in many prokaryotes and in virtually all eukaryotes [1].
  • A knockout of gshA, involved in glutathione biosynthesis, enhanced the susceptibility to metronidazole, while a knockout of recD, involved in recombination and repair, made the bacteria hypersusceptible to ciprofloxacin [2].


  1. Escherichia coli gamma-glutamylcysteine synthetase. Two active site metal ions affect substrate and inhibitor binding. Kelly, B.S., Antholine, W.E., Griffith, O.W. J. Biol. Chem. (2002) [Pubmed]
  2. Genes Involved in Intrinsic Antibiotic Resistance of Acinetobacter baylyi. Gomez, M.J., Neyfakh, A.A. Antimicrob. Agents Chemother. (2006) [Pubmed]
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