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Gene Review

Xpl  -  X-linked polydactyly

Mus musculus

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Disease relevance of Xpl


High impact information on Xpl

  • Degenerative changes occurring in the apical ectodermal ridge (a.e.r.) and undifferentiated distal mesoderm of developing limb buds were studied macro- and microscopically in day-11 to day-13 mouse embryos displaying the normal (+/+), oligosyndactylous (Os/+), polydactylous (Xpl/+) and hybrid (Os/+/Xpl/+) phenotypes [2].
  • Linkage tests show that Xpl is located on the distal end of the X chromosome with the order Ta--13--jp--15--Xpl [1].
  • However, observations made in explants excised from potentially polydactylous embryos showed that the X-linked polydactyly (Xpl) phenotype can be expressed in vitro [3].


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