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Gene Review:

Xpl - X-linked polydactyly

Mus musculus

Milaire, J., Sweet, H.O. et al., Milaire, J.

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Disease relevance of Xpl

A new X-linked dominant mutation in the mouse exhibiting preaxial polydactyly and tibial hemimelia is described and named X-linked polydactyly (Xpl) [1].

High impact information on Xpl

Degenerative changes occurring in the apical ectodermal ridge (a.e.r.) and undifferentiated distal mesoderm of developing limb buds were studied macro- and microscopically in day-11 to day-13 mouse embryos displaying the normal (+/+), oligosyndactylous (Os/+), polydactylous (Xpl/+) and hybrid (Os/+/Xpl/+) phenotypes [2].
Linkage tests show that Xpl is located on the distal end of the X chromosome with the order Ta--13--jp--15--Xpl [1].
However, observations made in explants excised from potentially polydactylous embryos showed that the X-linked polydactyly (Xpl) phenotype can be expressed in vitro [3].

References

X-linked polydactyly (Xpl), a new mutation in the mouse. Sweet, H.O., Lane, P.W. J. Hered. (1980) [Pubmed]
A new interpretation of the necrotic changes occurring in the developing limb bud paddle of mouse embryos based upon recent observations in four different phenotypes. Milaire, J. Int. J. Dev. Biol. (1992) [Pubmed]
Further analysis of developmental potentialities expressed by the footplate of 11-day mouse embryo hindlimb buds explanted in organ culture. Milaire, J. European journal of morphology. (1996) [Pubmed]

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