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Gene Review:

Prt1 - pancreatic proteinase 1

Mus musculus

Synonyms: Prt-1

Heise, M.T. et al., Watanabe, T. et al., Watanabe, T., Watanabe, T. et al.

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High impact information on Prt1

Isoleucine was introduced at position 538 in the wild-type S.A.AR86 infectious clone, ps55, and virus derived from this mutant clone, ps51, was significantly attenuated for neurovirulence compared to that derived from ps55 [1].
Genetic study of pancreatic proteinase in mice (Mus musculus): genetic variation at the Prt-1 locus as trypsinogen [2].
Genetic study of pancreatic proteinase in mice (Mus musculus): linkage of the Prt-2 locus on chromosome 8 [3].
The Prt-1 and Prt-3 loci, which are linked very closely on the same chromosome, were not determined [3].

Analytical, diagnostic and therapeutic context of Prt1

Various patterns of mouse pancreatic proteinase activity bands were observed on agarose gel electrophoresis [4].

References

A single amino acid change in nsP1 attenuates neurovirulence of the Sindbis-group alphavirus S.A.AR86. Heise, M.T., Simpson, D.A., Johnston, R.E. J. Virol. (2000) [Pubmed]
Genetic study of pancreatic proteinase in mice (Mus musculus): genetic variation at the Prt-1 locus as trypsinogen. Watanabe, T. Biochem. Genet. (1981) [Pubmed]
Genetic study of pancreatic proteinase in mice (Mus musculus): linkage of the Prt-2 locus on chromosome 8. Watanabe, T., Ogasawara, N., Goto, H. Biochem. Genet. (1976) [Pubmed]
Evolutionary relationships between laboratory mice and subspecies of Mus musculus based on the genetic study of pancreatic proteinase loci, Prt-1, Prt-2, Prt-3, and Prt-6. Watanabe, T., Miyashita, N., Moriwaki, K., Hilgers, J. Biochem. Genet. (1987) [Pubmed]

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