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Gene Review

CDC42EP3  -  CDC42 effector protein (Rho GTPase binding) 3

Homo sapiens

Synonyms: BORG2, Binder of Rho GTPases 2, CEP3, Cdc42 effector protein 3, MSE55-related Cdc42-binding protein, ...
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High impact information on CDC42EP3

  • We detected three CEP3 transcripts in the testis tissue including one which was highly expressed and testis specific by northern blotting [1].
  • These results support the hypothesis that CEP3 mRNA may be a target of PUMILIO2 protein in the human male gonad and be under translational control mediated by specific nucleotide motifs within the 3'UTR [1].

Analytical, diagnostic and therapeutic context of CDC42EP3

  • Interaction of PUMILIO2 with the fragment of CEP3 transcript containing the ABB array was tested by mobility shift assay and we found that PUMILIO2 binds the 3' untranslated region of the CEP3 mRNA [1].


  1. Human fertility protein PUMILIO2 interacts in vitro with testis mRNA encoding Cdc42 effector 3 (CEP3). Spik, A., Oczkowski, S., Olszak, A., Formanowicz, P., B??azewicz, J., Jaruzelska, J. Reproductive biology (2006) [Pubmed]
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