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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RRAGA  -  Ras-related GTP binding A

Homo sapiens

Synonyms: Adenovirus E3 14.7 kDa-interacting protein 1, FIP-1, FIP1, RAGA, Rag A, ...
 
 
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High impact information on RRAGA

  • RAGA: RNA sequence alignment by genetic algorithm [1].
  • The stable expression of FIP-1 antisense message partially protected the cells from TNF-alpha cytolysis [2].
  • FIP-1 has two consensus sequences for myristoylation which would be expected to facilitate membrane association and also has sequences for Ser/Thr as well as Tyr phosphorylation that could affect its function [2].
  • FIP-1 mRNA was expressed ubiquitously but at higher levels in human skeletal muscle, heart, and brain [2].
  • A new member of the low-molecular-weight (LMW) GTP-binding protein family with Ras and ADP-ribosylation factor homology was discovered by this selection and has been named FIP-1 (14.7K-interacting protein) [2].
 

Biological context of RRAGA

  • These data suggest that FIP-1, as a cellular target for Ad E3-14.7K, is either a new intermediate on a previously described pathway or part of a novel TNF-alpha-induced cell death pathway [2].
 

Anatomical context of RRAGA

 

Analytical, diagnostic and therapeutic context of RRAGA

  • FIP-1 was associated transiently with several unknown phosphorylated cellular proteins within 15 min after treatment with TNF-alpha [2].
  • RAGA is mainly an extension of SAGA, an earlier package for multiple protein sequence alignment [1].
  • This hypothesis was scientifically tested using sleep polysomnography with eight healthy subjects who listened to either Neelambari (test) raga or Kalyani (control) raga [3].

References

  1. RAGA: RNA sequence alignment by genetic algorithm. Notredame, C., O'Brien, E.A., Higgins, D.G. Nucleic Acids Res. (1997) [Pubmed]
  2. Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers. Li, Y., Kang, J., Horwitz, M.S. J. Virol. (1997) [Pubmed]
  3. Effect of the Karnatic music raga "Neelambari" on sleep architecture. Gitanjali, B. Indian J. Physiol. Pharmacol. (1998) [Pubmed]
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