Gene Review:
Ubxn8 - UBX domain protein 8
Mus musculus
Synonyms:
D0H8S2298E, Rep-8, Rep-8 protein, Rep8, Rep8h, ...
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High impact information on Ubxd6
- The overall amino acid sequence homology between mouse and human Rep-8 proteins was 73%, and the overall nucleic acid sequence similarity was 65% [1].
- The predicted amino acid sequence of mouse Rep-8 has leucine zipper-like motifs in the N-terminal region, similar to the human Rep-8 protein [1].
- Rep-8 exists as a single-copy gene and is expressed in both the early and late embryonic stages of mouse development, suggesting that the Rep-8 gene product has an important role in embryogenesis [1].
Analytical, diagnostic and therapeutic context of Ubxd6
- A mouse homologue of the human Rep-8 gene was cloned by PCR methods using degenerate oligonucleotide primers corresponding to highly conserved regions between human and mouse genes, and by the Marathon-Ready cDNA amplification method [1].
- The genomic structure of the mouse Rep-8 gene was characterized extensively so that a gene targeting strategy could be used to develop an understanding of the biological function(s) of this interesting gene and its product [1].
References
- Structures of mouse Rep-8 cDNA and genomic clones. Yamabe, Y., Yokoi, A., Imamura, O., Matsui, M., Matsunaga, A., Taketo, M., Sugawara, M., Furuichi, Y. Gene (1999) [Pubmed]
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