The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Luzp1  -  leucine zipper protein 1

Mus musculus

Synonyms: 2700072H04Rik, AI266952, Leucine zipper motif-containing protein, Leucine zipper protein 1, Luzp, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Luzp1

  • Two leucine zipper libraries, semi-randomized at the positions adjacent to the hydrophobic core, were genetically fused to either one of two designed fragments of the enzyme murine dihydrofolate reductase (mDHFR), and cotransformed into Escherichia coli [1].
  • The leucine zipper of c-Myc is required for full inhibition of erythroleukemia differentiation [2].
  • Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains [3].
  • Expressed proteins were anchored to the phage coat by a synthetic, anti-parallel leucine zipper, which had been selected from a semi-randomized zipper library for the ability to connect a test protein to phage [4].
  • Moreover, leucine zipper TRAIL has no toxicity when repeatedly administered to osteoprotegerin(-/-) mice [5].

High impact information on Luzp1


Chemical compound and disease context of Luzp1


Biological context of Luzp1


Anatomical context of Luzp1


Associations of Luzp1 with chemical compounds

  • The SEN1 protein contains a leucine zipper motif, consensus elements for nucleoside triphosphate binding, and a potential nuclear localization signal sequence [21].
  • Activating transcription factor (ATF) 4 is a ubiquitous basic leucine-zipper transcription factor that is a member of the ATF/cyclic adenosine monophosphate responsive element-binding (CREB) protein family [22].
  • Mixed lineage kinases (MLKs) form a family of serin/threonine protein kinases with multiple protein/protein interaction domains (SH3, Cdc42 Rac interactive binding sequence, leucine zipper, and proline rich region), the physiological roles of which are largely unknown [23].
  • The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes [24].
  • The DNA regulatory sequence responsible for mediating glucose and cyclic AMP responses, called glucose response element (GlRE), consists of two degenerated E boxes spaced by 5 base pairs and is able to bind basic helix-loop-helix/leucine zipper proteins, in particular the upstream stimulatory factors (USFs) [25].

Physical interactions of Luzp1

  • Here we report that AKAP15 directly interacts with the C-terminal domain of the alpha(1) subunit of Ca(V)1.1 via a leucine zipper (LZ) motif [26].
  • cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein [27].
  • Furthermore, the FcRgamma residues interacting with FcalphaRI form a leucine zipper-like interface with mutagenesis confirming a complementary interface comprising FcalphaRI residues Leu-217, Leu-220, and Leu-224 [28].
  • West-Western screening of a cDNA expression library using 32P-labeled, autophosphorylated protein kinase Cdelta (PKCdelta) as a probe, led us to identify cDNA clones encoding a PKCdelta-binding protein that contains a leucine zipper-like motif in its N-terminal region and two PEST sequences in its C-terminal region [29].
  • These data support the hypothesis that dystrophin couples the contractile apparatus to the sarcolemma and indicate that leucine zipper mediated protein-protein interactions are functionally important in the cytoskeleton as well as the nucleus [30].

Regulatory relationships of Luzp1

  • Dominant-negative CHOP-10 is initially expressed by growth-arrested preadipocytes and sequesters/inactivates C/EBPbeta by heterodimerization with its leucine zipper [31].
  • Nuclear translocation of Fos is stimulated by interaction with Jun through the leucine zipper [32].

Other interactions of Luzp1


Analytical, diagnostic and therapeutic context of Luzp1


  1. An in vivo library-versus-library selection of optimized protein-protein interactions. Pelletier, J.N., Arndt, K.M., Plückthun, A., Michnick, S.W. Nat. Biotechnol. (1999) [Pubmed]
  2. The leucine zipper of c-Myc is required for full inhibition of erythroleukemia differentiation. Smith, M.J., Charron-Prochownik, D.C., Prochownik, E.V. Mol. Cell. Biol. (1990) [Pubmed]
  3. Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains. Li, Y., Kang, J., Horwitz, M.S. Mol. Cell. Biol. (1998) [Pubmed]
  4. Expression cloning of cDNA by phage display selection. Light, J., Maki, R., Assa-Munt, N. Nucleic Acids Res. (1996) [Pubmed]
  5. Characterization of the in vivo function of TNF-alpha-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice. Sedger, L.M., Glaccum, M.B., Schuh, J.C., Kanaly, S.T., Williamson, E., Kayagaki, N., Yun, T., Smolak, P., Le, T., Goodwin, R., Gliniak, B. Eur. J. Immunol. (2002) [Pubmed]
  6. Par-4 links dopamine signaling and depression. Park, S.K., Nguyen, M.D., Fischer, A., Luke, M.P., Affar, e.l. .B., Dieffenbach, P.B., Tseng, H.C., Shi, Y., Tsai, L.H. Cell (2005) [Pubmed]
  7. trans-repression of the mouse c-fos promoter: a novel mechanism of Fos-mediated trans-regulation. Lucibello, F.C., Lowag, C., Neuberg, M., Müller, R. Cell (1989) [Pubmed]
  8. CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP. Ripperger, J.A., Shearman, L.P., Reppert, S.M., Schibler, U. Genes Dev. (2000) [Pubmed]
  9. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Yeh, W.C., Cao, Z., Classon, M., McKnight, S.L. Genes Dev. (1995) [Pubmed]
  10. A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death. D'Adamio, F., Zollo, O., Moraca, R., Ayroldi, E., Bruscoli, S., Bartoli, A., Cannarile, L., Migliorati, G., Riccardi, C. Immunity (1997) [Pubmed]
  11. A leucine zipper motif in the cytoplasmic domain of gp41 is required for HIV-1 replication and pathogenesis in vivo. Kao, S.M., Miller, E.D., Su, L. Virology (2001) [Pubmed]
  12. Restricted expression of LUZP in neural lineage cells: a study in embryonic stem cells. Lee, M.W., Chang, A.C., Sun, D.S., Hsu, C.Y., Chang, N.C. J. Biomed. Sci. (2001) [Pubmed]
  13. The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior. Lopez-Molina, L., Conquet, F., Dubois-Dauphin, M., Schibler, U. EMBO J. (1997) [Pubmed]
  14. Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. Chan, J.Y., Kwong, M., Lu, R., Chang, J., Wang, B., Yen, T.S., Kan, Y.W. EMBO J. (1998) [Pubmed]
  15. Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun. Fahmy, R.G., Waldman, A., Zhang, G., Mitchell, A., Tedla, N., Cai, H., Geczy, C.R., Chesterman, C.N., Perry, M., Khachigian, L.M. Nat. Biotechnol. (2006) [Pubmed]
  16. CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling. Zhu, S., Yoon, K., Sterneck, E., Johnson, P.F., Smart, R.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  17. Importance of leucine zipper domain of mi transcription factor (MITF) for differentiation of mast cells demonstrated using mi(ce)/mi(ce) mutant mice of which MITF lacks the zipper domain. Morii, E., Ogihara, H., Kim, D.K., Ito, A., Oboki, K., Lee, Y.M., Jippo, T., Nomura, S., Maeyama, K., Lamoreux, M.L., Kitamura, Y. Blood (2001) [Pubmed]
  18. A gene that is related to SRY and is expressed in the testes encodes a leucine zipper-containing protein. Takamatsu, N., Kanda, H., Tsuchiya, I., Yamada, S., Ito, M., Kabeno, S., Shiba, T., Yamashita, S. Mol. Cell. Biol. (1995) [Pubmed]
  19. Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP. Lavery, D.J., Lopez-Molina, L., Margueron, R., Fleury-Olela, F., Conquet, F., Schibler, U., Bonfils, C. Mol. Cell. Biol. (1999) [Pubmed]
  20. Combinatorial determinants of tissue-specific transcription in B cells and macrophages. Nikolajczyk, B.S., Cortes, M., Feinman, R., Sen, R. Mol. Cell. Biol. (1997) [Pubmed]
  21. SEN1, a positive effector of tRNA-splicing endonuclease in Saccharomyces cerevisiae. DeMarini, D.J., Winey, M., Ursic, D., Webb, F., Culbertson, M.R. Mol. Cell. Biol. (1992) [Pubmed]
  22. Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Masuoka, H.C., Townes, T.M. Blood (2002) [Pubmed]
  23. The JNK/SAPK activator mixed lineage kinase 3 (MLK3) transforms NIH 3T3 cells in a MEK-dependent fashion. Hartkamp, J., Troppmair, J., Rapp, U.R. Cancer Res. (1999) [Pubmed]
  24. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. McMahon, M., Itoh, K., Yamamoto, M., Chanas, S.A., Henderson, C.J., McLellan, L.I., Wolf, C.R., Cavin, C., Hayes, J.D. Cancer Res. (2001) [Pubmed]
  25. Chicken ovalbumin upstream promoter-transcription factor II, a new partner of the glucose response element of the L-type pyruvate kinase gene, acts as an inhibitor of the glucose response. Lou, D.Q., Tannour, M., Selig, L., Thomas, D., Kahn, A., Vasseur-Cognet, M. J. Biol. Chem. (1999) [Pubmed]
  26. A novel leucine zipper targets AKAP15 and cyclic AMP-dependent protein kinase to the C terminus of the skeletal muscle Ca2+ channel and modulates its function. Hulme, J.T., Ahn, M., Hauschka, S.D., Scheuer, T., Catterall, W.A. J. Biol. Chem. (2002) [Pubmed]
  27. cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein. Nishizawa, M., Nagata, S. FEBS Lett. (1992) [Pubmed]
  28. A common site of the Fc receptor gamma subunit interacts with the unrelated immunoreceptors FcalphaRI and FcepsilonRI. Wines, B.D., Trist, H.M., Ramsland, P.A., Hogarth, P.M. J. Biol. Chem. (2006) [Pubmed]
  29. A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation. Izumi, Y., Hirai, S., Tamai, Y., Fujise-Matsuoka, A., Nishimura, Y., Ohno, S. J. Biol. Chem. (1997) [Pubmed]
  30. Troponin T is capable of binding dystrophin via a leucine zipper. Pearlman, J.A., Powaser, P.A., Elledge, S.J., Caskey, C.T. FEBS Lett. (1994) [Pubmed]
  31. Effect of serum on the down-regulation of CHOP-10 during differentiation of 3T3-L1 preadipocytes. Huang, H., Lane, M.D., Tang, Q.Q. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  32. Nuclear translocation of Fos is stimulated by interaction with Jun through the leucine zipper. Chida, K., Nagamori, S., Kuroki, T. Cell. Mol. Life Sci. (1999) [Pubmed]
  33. Semirational design of Jun-Fos coiled coils with increased affinity: Universal implications for leucine zipper prediction and design. Mason, J.M., Schmitz, M.A., Müller, K.M., Arndt, K.M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  34. Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. Chevray, P.M., Nathans, D. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  35. The maf proto-oncogene stimulates transcription from multiple sites in a promoter that directs Purkinje neuron-specific gene expression. Kurschner, C., Morgan, J.I. Mol. Cell. Biol. (1995) [Pubmed]
  36. Additive effect of mouse genetic background and mutation of MITF gene on decrease of skin mast cells. Morii, E., Oboki, K., Jippo, T., Kitamura, Y. Blood (2003) [Pubmed]
  37. Cell-free cotranslation and selection using in vitro virus for high-throughput analysis of protein-protein interactions and complexes. Miyamoto-Sato, E., Ishizaka, M., Horisawa, K., Tateyama, S., Takashima, H., Fuse, S., Sue, K., Hirai, N., Masuoka, K., Yanagawa, H. Genome Res. (2005) [Pubmed]
  38. High-level production of a secreted, heterodimeric alpha beta murine T-cell receptor in Escherichia coli. Golden, A., Khandekar, S.S., Osburne, M.S., Kawasaki, E., Reinherz, E.L., Grossman, T.H. J. Immunol. Methods (1997) [Pubmed]
  39. The mouse Sox5 gene encodes a protein containing the leucine zipper and the Q box. Hiraoka, Y., Ogawa, M., Sakai, Y., Kido, S., Aiso, S. Biochim. Biophys. Acta (1998) [Pubmed]
WikiGenes - Universities