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Gene Review

bla1  -  beta-lactamase Bla1

Bacillus anthracis str. Ames

 
 
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Disease relevance of bla1

 

High impact information on bla1

  • In a penicillin-resistant clinical isolate, both genes are highly transcribed, but bla1 is the major contributor to high-level resistance to ampicillin [1].
 

Biological context of bla1

  • Taken together, these data indicate that the bla1 and bla2 genes of the B. anthracis Sterne strain encode functional beta-lactamases of different types, but gene expression is usually not sufficient to confer resistance to beta-lactam agents [2].

References

  1. Beta-lactamase gene expression in a penicillin-resistant Bacillus anthracis strain. Chen, Y., Tenover, F.C., Koehler, T.M. Antimicrob. Agents Chemother. (2004) [Pubmed]
  2. Beta-lactamase genes of the penicillin-susceptible Bacillus anthracis Sterne strain. Chen, Y., Succi, J., Tenover, F.C., Koehler, T.M. J. Bacteriol. (2003) [Pubmed]
 
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