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EHMT2  -  euchromatic histone-lysine N...

Homo sapiens

Synonyms: BAT8, C6orf30, Em:AF134726.3, Euchromatic histone-lysine N-methyltransferase 2, G9A, ...
 
 
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Disease relevance of EHMT2

  • Finally, small interfering RNA (siRNA)-mediated knockdown of G9A and DNMT1 led to increased MASPIN expression in MDA-MB-231 cells, to levels that were supra-additive, verifying the importance of these enzymes in maintaining multiple layers of epigenetic repression in breast tumor cells [1].
 

High impact information on EHMT2

  • A specific immunoaffinity-purified rabbit anti-hBAT polyclonal antibody was used to screen a lambda Zap XR human liver cDNA library resulting in the isolation of two unique clones. hBAT8 and hBAT9 (1669 and 1491 base pairs in length, respectively) were isolated following screening of 4 x 10(5) clones of the cDNA library [2].
  • 5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation [1].
  • However, a trend was observed: homozygotes for the rare alleles of the EHMT1, EHMT2 and PRDM2 had a mean value for both trimethylation of K9 and K27 of histone H3 remarkably different to the homozygotes for the common alleles [3].
  • The complete nucleotide sequence of a 3.4 kb mRNA from one of these genes, G9a (or BAT8), has been determined from cDNA and genomic DNA clones [4].

References

  1. 5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation. Wozniak, R.J., Klimecki, W.T., Lau, S.S., Feinstein, Y., Futscher, B.W. Oncogene (2007) [Pubmed]
  2. Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. Falany, C.N., Johnson, M.R., Barnes, S., Diasio, R.B. J. Biol. Chem. (1994) [Pubmed]
  3. Genetic variants in epigenetic genes and breast cancer risk. Cebrian, A., Pharoah, P.D., Ahmed, S., Ropero, S., Fraga, M.F., Smith, P.L., Conroy, D., Luben, R., Perkins, B., Easton, D.F., Dunning, A.M., Esteller, M., Ponder, B.A. Carcinogenesis (2006) [Pubmed]
  4. The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats. Milner, C.M., Campbell, R.D. Biochem. J. (1993) [Pubmed]
 
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