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Gene Review

SERPINB5  -  serpin peptidase inhibitor, clade B...

Homo sapiens

Synonyms: Maspin, PI-5, PI5, Peptidase inhibitor 5, Serpin B5, ...
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Disease relevance of SERPINB5


High impact information on SERPINB5


Chemical compound and disease context of SERPINB5


Biological context of SERPINB5


Anatomical context of SERPINB5

  • Subcellular fractionation shows that a fraction of maspin (in both TM40D-Mp and mutant maspinDeltaN cells) translocates to the mitochondria [1].
  • To address this issue, we generated stable maspin-expressing transfectants using prostate carcinoma cells DU145 as the parental cell line [11].
  • In tumor tissues, maspin expression was associated with lymph node involvement (P = 0.035) and tumor stage (P = 0.063) in all tested cases, except squamous carcinoma [2].
  • We confirmed the maspin/GST interaction using purified proteins, human epithelial cell lines, and human prostate tissues [3].
  • This study indicates that maspin protein possibly functions as a clinically relevant inhibitor of tumor progression, preventing local invasiveness and further systemic progression of papillary thyroid carcinomas [12].

Associations of SERPINB5 with chemical compounds


Physical interactions of SERPINB5

  • We have also demonstrated the binding of p63 protein to a previously identified p53-binding site on the maspin promoter by gel shift and chromatin immunoprecipitation assays [2].
  • Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership [10].
  • Further biochemical and biophysical analyses revealed that maspin specifically bound to pro-uPA with a deduced K(d) of 270 nmol/L and inhibited the plasmin-mediated pro-uPA cleavage [15].

Regulatory relationships of SERPINB5


Other interactions of SERPINB5


Analytical, diagnostic and therapeutic context of SERPINB5

  • Maspin-expressing mammary tumors are more susceptible to apoptosis in both implanted mammary tumors in vivo, a three-dimensional spheroid culture system, as well as in monolayer cell culture under lowered growth factors [1].
  • To this end, we used a full-length maspin cDNA bait to screen against both a primary prostate tumor cDNA prey library and a HeLa cDNA prey library by the yeast two-hybrid method [3].
  • We developed a real-time quantitative RT-PCR assay to quantify the full range of maspin mRNA copy numbers in a series of 10 ER alpha-positive and 10 ER alpha-negative breast tumours [7].
  • The first aim of our study was to determine the prognostic value of maspin protein expression for the recurrence-free and overall survival of PTC patients undergoing radical thyroidectomy and postoperative irradiation [12].
  • The lack of maspin expression in breast cancer seems to be associated with a short disease-free survival and supports maspin's function as an indicator for tumor aggressiveness and metastatic potential [8].


  1. Maspin mediates increased tumor cell apoptosis upon induction of the mitochondrial permeability transition. Latha, K., Zhang, W., Cella, N., Shi, H.Y., Zhang, M. Mol. Cell. Biol. (2005) [Pubmed]
  2. Maspin expression is transactivated by p63 and is critical for the modulation of lung cancer progression. Kim, S., Han, J., Kim, J., Park, C. Cancer Res. (2004) [Pubmed]
  3. Tumor-suppressive maspin regulates cell response to oxidative stress by direct interaction with glutathione S-transferase. Yin, S., Li, X., Meng, Y., Finley, R.L., Sakr, W., Yang, H., Reddy, N., Sheng, S. J. Biol. Chem. (2005) [Pubmed]
  4. Role for DNA methylation in the control of cell type specific maspin expression. Futscher, B.W., Oshiro, M.M., Wozniak, R.J., Holtan, N., Hanigan, C.L., Duan, H., Domann, F.E. Nat. Genet. (2002) [Pubmed]
  5. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Zou, Z., Anisowicz, A., Hendrix, M.J., Thor, A., Neveu, M., Sheng, S., Rafidi, K., Seftor, E., Sager, R. Science (1994) [Pubmed]
  6. Maspin sensitizes prostate cancer cells to doxazosin-induced apoptosis. Tahmatzopoulos, A., Sheng, S., Kyprianou, N. Oncogene (2005) [Pubmed]
  7. Prognostic value of maspin mRNA expression in ER alpha-positive postmenopausal breast carcinomas. Bièche, I., Girault, I., Sabourin, J.C., Tozlu, S., Driouch, K., Vidaud, M., Lidereau, R. Br. J. Cancer (2003) [Pubmed]
  8. Expression and regulation of tumor suppressor gene maspin in breast cancer. Maass, N., Nagasaki, K., Ziebart, M., Mundhenke, C., Jonat, W. Clin. Breast Cancer (2002) [Pubmed]
  9. Epigenetic regulation of maspin expression in human ovarian carcinoma cells. Rose, S.L., Fitzgerald, M.P., White, N.O., Hitchler, M.J., Futscher, B.W., De Geest, K., Domann, F.E. Gynecol. Oncol. (2006) [Pubmed]
  10. Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership. Bailey, C.M., Khalkhali-Ellis, Z., Kondo, S., Margaryan, N.V., Seftor, R.E., Wheaton, W.W., Amir, S., Pins, M.R., Schutte, B.C., Hendrix, M.J. J. Biol. Chem. (2005) [Pubmed]
  11. Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin. Biliran, H., Sheng, S. Cancer Res. (2001) [Pubmed]
  12. Maspin in thyroid cancer: its relationship with p53 and clinical outcome. Boltze, C., Schneider-Stock, R., Meyer, F., Peters, B., Quednow, C., Hoang-Vu, C., Roessner, A. Oncol. Rep. (2003) [Pubmed]
  13. Loss of maspin expression is associated with development and progression of gastric carcinoma with p53 abnormality. Ito, R., Nakayama, H., Yoshida, K., Oda, N., Yasui, W. Oncol. Rep. (2004) [Pubmed]
  14. Tamoxifen induces the expression of maspin through estrogen receptor-alpha. Liu, Z., Shi, H.Y., Nawaz, Z., Zhang, M. Cancer Lett. (2004) [Pubmed]
  15. Maspin retards cell detachment via a novel interaction with the urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor system. Yin, S., Lockett, J., Meng, Y., Biliran, H., Blouse, G.E., Li, X., Reddy, N., Zhao, Z., Lin, X., Anagli, J., Cher, M.L., Sheng, S. Cancer Res. (2006) [Pubmed]
  16. TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressor. Spiesbach, K., Tannapfel, A., Mössner, J., Engeland, K. Int. J. Cancer (2005) [Pubmed]
  17. The surface of prostate carcinoma DU145 cells mediates the inhibition of urokinase-type plasminogen activator by maspin. McGowen, R., Biliran, H., Sager, R., Sheng, S. Cancer Res. (2000) [Pubmed]
  18. Pathobiological significance of vascular endothelial growth factor and Maspin expressions in human gastric carcinoma. Li, J.J., Chen, Y., Zhang, S.M., Wu, D.Y., Wang, Y.P., Xin, Y. World J. Gastroenterol. (2004) [Pubmed]
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