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Gene Review:

Lbw4 - lupus NZB x NZW 4

Mus musculus

Xie, S. et al., Xie, S. et al.

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Disease relevance of Lbw4

CONCLUSION: Considering all 3 mapping studies together, lupus in SWR/NZB hybrids appears to be the epistatic end product of several distinct loci, of which 3 SWR-derived loci (Swrl-1, Swrl-2, and Swrl-3) and 5 NZB-derived loci (Nba1, Nba3, Nba4, Nba5, and Lbw4) have been independently confirmed [1].

High impact information on Lbw4

A second study focusing on SNF(1) x SWR backcross offspring uncovered 5 suggestive loci for antinuclear antibody formation, consisting of 3 dominant NZB contributions (Nba4 on chromosome 5, Lbw4 on chromosome 6, and Nba5 on chromosome 7) and 2 recessive SWR contributions (Swrl-1 on chromosome 1 and Swrl-4 on chromosome 10) [1].
The present study focusing on a panel of 88 SWR x SNF1 backcross mice reveals the existence of five suggestive loci for antinuclear antibody formation, consisting of three dominant NZB contributions (Nba4 on Chr 5, Lbw4 on Chr 6, and Nba5 on Chr 7), and two recessive SWR contributions (Swrl-1 on Chr 1, and Swrl-4 on Chr 10) [2].

References

Genetic origin of lupus in NZB/SWR hybrids: lessons from an intercross study. Xie, S., Li, L., Chang, S., Sharma, R., Kaliyaperumal, A., Datta, S.K., Mohan, C. Arthritis Rheum. (2005) [Pubmed]
Dominant NZB contributions to lupus in the (SWR x NZB)F1 model. Xie, S., Chang, S.H., Sedrak, P., Kaliyaperumal, A., Datta, S.K., Mohan, C. Genes Immun. (2002) [Pubmed]

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