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Gene Review

D5Kng3  -  DNA segment, Chr 5, Kingsley 3

Mus musculus

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Disease relevance of D5Kng3

  • A locus on Chr 5 (Skts4) was found to control the susceptibility of SENCARA/Pt mice and the resistance of BALB/cAnPt mice to papilloma formation [1].
  • This finding led us to propose the existence of an important plasmacytoma progression locus in the central region of Chr 5, which presumably becomes involved in peritoneal plasmacytoma development by promiscuous chromosomal translocations [2].
  • A novel mouse Chr5 locus Diht controls dopamine-induced hypothermia [3].
  • Whether the candidate QTLs on Chr 5 affect arm choice through an effect on light perception is unknown, but phenotypic differences between F2 mice with retinal degeneration and CBA/J mice and F2 mice with albinism and A/J mice suggest that factors other than light sensitivity contribute to arm preference in these two strains [4].

High impact information on D5Kng3

  • A third gene, tda3, on Chr 5 is implicated, but the evidence here is not as strong [5].
  • The mouse PSGL-1 gene, Selpl, was mapped to a position on mouse chromosome 5 (Chr 5) [6].
  • A region-specific ENU mutagenesis screen was conducted to elucidate the functional content of proximal mouse Chr 5 [7].
  • Test-class animals, homozygous for the ENU-mutagenized proximal Chr 5 and visibly distinguishable from nonhomozygous littermates, were screened for fertility, hearing, vestibular function, DNA repair, behavior, and dysmorphology [7].
  • The locus on Chr 5 exhibited lod scores of 3.8 for total cholesterol and 4.1 for unesterified cholesterol in mice fed an atherogenic diet, and this locus has been observed in 2 previous studies [8].

Biological context of D5Kng3

  • Eleven of 20 cDNA clones mapped to three mouse autosomes (Chr 5, 11, and 14), a result that was unlikely (P < 0.03) if the distribution of genes expressed in embryos is random within the mouse genome [9].
  • The human IPF1 gene homolog would be expected to map to either chromosome 13q12-q14 or 7pter-q21 based on homology of synteny of other loci in this region of mouse Chr 5 [10].
  • The present study focusing on a panel of 88 SWR x SNF1 backcross mice reveals the existence of five suggestive loci for antinuclear antibody formation, consisting of three dominant NZB contributions (Nba4 on Chr 5, Lbw4 on Chr 6, and Nba5 on Chr 7), and two recessive SWR contributions (Swrl-1 on Chr 1, and Swrl-4 on Chr 10) [11].
  • The Peplb locus, encoding a CD26 ectopeptidase-like neuronal membrane protein activated by kainate and long-term potentiation, mapped to Chr 5 [12].
  • We detected 67 suggestive linkages for six phenotypes, which fell into one of three categories: those specific to absolute but not relative depot weight (Chr 5, 11, and 14), those specific to relative but not absolute depot weight (Chr 9, 15, and 16), and those involving both (Chr 2 and 7) [13].

Associations of D5Kng3 with chemical compounds

  • Parallel studies in F1 and F2 heterozygote mice showed that the high sensitivity to hypothermic effect of dopamine (Dih-thigh) is inherited as the Chr5-linked dominant trait [3].
  • Karyotypic analysis based on G-banding and quinacrine/Hoechst-banding studies revealed a morphological similarity between the additional segment of Chr 5 and the centromeric region of Chr 12 [14].

Physical interactions of D5Kng3

  • In this linkage map, the Jun and A8 loci are newly placed, and two previously reported linkage groups on rat Chr 5 are connected by the Jun locus [15].

Other interactions of D5Kng3

  • Physical maps of the CXC chemokine clusters on murine Chr 5 and human Chr 21 were constructed using the Celera mouse genome database and the public human genome database [16].
  • The mrct locus was closely linked to D5Mit239 (chi2 = 66.3, P << 0.00001) on Chr 5 [17].
  • In addition, a Gm2a-related sequence (Gm2a-rs1) was mapped to mouse Chr 5 [18].
  • The proximal flanking marker, D5Mit68, maps to a segment on mouse Chr 5 homologous to human Chr 4 [19].
  • As expected, both Idua and D4S115h are located on the proximal portion of mouse Chr 5 near homologs for other loci on human Chr 4p [20].

Analytical, diagnostic and therapeutic context of D5Kng3


  1. Multigenic control of skin tumor susceptibility in SENCARA/Pt mice. Mock, B.A., Lowry, D.T., Rehman, I., Padlan, C., Yuspa, S.H., Hennings, H. Carcinogenesis (1998) [Pubmed]
  2. Recurrent non-reciprocal translocations of chromosome 5 in primary T(12;15)-positive BALB/c plasmacytomas. Coleman, A.E., Ried, T., Janz, S. Curr. Top. Microbiol. Immunol. (1999) [Pubmed]
  3. A novel mouse Chr5 locus Diht controls dopamine-induced hypothermia. Stoddart, C.W., Martin-Iverson, M.T., Jablensky, A., Urosevi, N. Mamm. Genome (2004) [Pubmed]
  4. Quantitative trait loci affecting the behavior of A/J and CBA/J intercross mice in the elevated plus maze. Cohen, R.M., Kang, A., Gulick, C. Mamm. Genome (2001) [Pubmed]
  5. Sex-determining genes on mouse autosomes identified by linkage analysis of C57BL/6J-YPOS sex reversal. Eicher, E.M., Washburn, L.L., Schork, N.J., Lee, B.K., Shown, E.P., Xu, X., Dredge, R.D., Pringle, M.J., Page, D.C. Nat. Genet. (1996) [Pubmed]
  6. Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor. Yang, J., Galipeau, J., Kozak, C.A., Furie, B.C., Furie, B. Blood (1996) [Pubmed]
  7. Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations. Wilson, L., Ching, Y.H., Farias, M., Hartford, S.A., Howell, G., Shao, H., Bucan, M., Schimenti, J.C. Genome Res. (2005) [Pubmed]
  8. Quantitative trait locus analysis of plasma lipoprotein levels in an autoimmune mouse model : interactions between lipoprotein metabolism, autoimmune disease, and atherogenesis. Gu, L., Johnson, M.W., Lusis, A.J. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  9. Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering. Tchernev, V.T., Barbosa, M.D., Detter, J.C., Patel, T.D., Achey, K., Wakeland, E.K., Gueorguieva, R.V., Yang, M.C., Gossler, A., Kingsmore, S.F. Genomics (1997) [Pubmed]
  10. Mapping of the insulin promoter factor 1 gene (Ipf1) to distal mouse chromosome 5. Fiedorek, F.T., Kay, E.S. Genomics (1995) [Pubmed]
  11. Dominant NZB contributions to lupus in the (SWR x NZB)F1 model. Xie, S., Chang, S.H., Sedrak, P., Kaliyaperumal, A., Datta, S.K., Mohan, C. Genes Immun. (2002) [Pubmed]
  12. Chromosomal mapping of mouse genes expressed selectively within the central nervous system. Danielson, P.E., Watson, J.B., Gerendasy, D.D., Erlander, M.G., Lovenberg, T.W., de Lecea, L., Sutcliffe, J.G., Frankel, W.N. Genomics (1994) [Pubmed]
  13. Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ x 129P3/J F(2) mice. Reed, D.R., McDaniel, A.H., Li, X., Tordoff, M.G., Bachmanov, A.A. Mamm. Genome (2006) [Pubmed]
  14. Segmental tetrasomy of chromosome 12 in the mouse. Katoh, H., Ebukuro, M., Suzuki, H. Cytogenet. Cell Genet. (1994) [Pubmed]
  15. A genetic linkage map of rat chromosome 5 reveals extensive linkage conservation with mouse chromosome 4. Kobayashi, E., Tachibana, M., Ikadai, H., Kunieda, T. Mamm. Genome (1994) [Pubmed]
  16. Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5. Smith, J.B., Wadleigh, D.J., Xia, Y.R., Mar, R.A., Herschman, H.R., Lusis, A.J. Immunogenetics (2002) [Pubmed]
  17. Two interactive genes responsible for a new inherited cataract (RCT) in the mouse. Maeda, Y.Y., Funata, N., Takahama, S., Sugata, Y., Yonekawa, H. Mamm. Genome (2001) [Pubmed]
  18. The mouse gene encoding the GM2 activator protein (Gm2a): cDNA sequence, expression, and chromosome mapping. Yamanaka, S., Johnson, O.N., Lyu, M.S., Kozak, C.A., Proia, R.L. Genomics (1994) [Pubmed]
  19. Low resolution mapping around the flavivirus resistance locus (Flv) on mouse chromosome 5. Urosevic, N., Mansfield, J.P., Mackenzie, J.S., Shellam, G.R. Mamm. Genome (1995) [Pubmed]
  20. Linkage, but not gene order, of homologous loci, including alpha-L-iduronidase (Idua), is conserved in the Huntington disease region of the mouse and human genomes. Koizumi, T., MacDonald, M., Búcan, M., Hopwood, J.J., Morris, C.P., Scott, H.S., Gusella, J.F., Nadeau, J.H. Mamm. Genome (1992) [Pubmed]
  21. The thrombospondin-4 gene. Newton, G., Weremowicz, S., Morton, C.C., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Lawler, J. Mamm. Genome (1999) [Pubmed]
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