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Gene Review

Nba1  -  New Zealand Black autoimmunity 1

Mus musculus

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Disease relevance of Nba1

  • Interestingly, a distal chromosome 4 locus, Nba1, was linked with nephritis but not with any of the autoantibodies measured, suggesting that it contributes to renal disease at a checkpoint distal to autoantibody production [1].
  • Susceptibility to glomerulonephritis was linked to H2 (Chr 17, LOD = 2.37 - 2.70), Swrl-2 (Chr 14, 36 cM, LOD = 2.48 - 2.71), and Nba1 (Chr 4, 75 cM, LOD = 2.15 - 2.23) [2].
  • CONCLUSION: Considering all 3 mapping studies together, lupus in SWR/NZB hybrids appears to be the epistatic end product of several distinct loci, of which 3 SWR-derived loci (Swrl-1, Swrl-2, and Swrl-3) and 5 NZB-derived loci (Nba1, Nba3, Nba4, Nba5, and Lbw4) have been independently confirmed [3].

High impact information on Nba1

  • This locus, designated here as nba-1 (New Zealand Black autoimmunity), lies distal to the locus elp-1, 60-70 centimorgans from the centromere [4].
  • Linkage analysis revealed four dominant SWR susceptibility loci (H2, Swrl-1, Swrl-2, and Swrl-3) and a recessive NZB locus, Nba1 [2].
  • Analysis of NZB x SNF1 backcross mice has recently revealed the existence of four dominant SWR loci (H2 on Chr 17, Swrl-1 on Chr 1, Swrl-2 on Chr 14 and Swrl-3 on Chr 18), and two NZB loci (Nba1 and Lbw2/Sbw2, both on Chr 4) conferring lupus susceptibility [5].


  1. Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice. Vyse, T.J., Drake, C.G., Rozzo, S.J., Roper, E., Izui, S., Kotzin, B.L. J. Clin. Invest. (1996) [Pubmed]
  2. Genetic contributions of nonautoimmune SWR mice toward lupus nephritis. Xie, S., Chang, S., Yang, P., Jacob, C., Kaliyaperumal, A., Datta, S.K., Mohan, C. J. Immunol. (2001) [Pubmed]
  3. Genetic origin of lupus in NZB/SWR hybrids: lessons from an intercross study. Xie, S., Li, L., Chang, S., Sharma, R., Kaliyaperumal, A., Datta, S.K., Mohan, C. Arthritis Rheum. (2005) [Pubmed]
  4. Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice. Drake, C.G., Babcock, S.K., Palmer, E., Kotzin, B.L. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  5. Dominant NZB contributions to lupus in the (SWR x NZB)F1 model. Xie, S., Chang, S.H., Sedrak, P., Kaliyaperumal, A., Datta, S.K., Mohan, C. Genes Immun. (2002) [Pubmed]
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