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Gene Review:

Lore1 - loss of righting induced by ethanol 1

Mus musculus

Ehringer, M.A. et al., Bennett, B. et al., Bennett, B. et al., Proctor, W.R. et al., Owens, J.C. et al.

Bennett, Beeson, Gordon, Carosone-Link, Johnson, Proctor, Wu, Bennett, Johnson,

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High impact information on Lore1

CONCLUSIONS: Our results suggest that alleles located in the Lore1 and Lore4 QTL regions confer ethanol sensitivity of GABAA receptor-mediated IPSCs [1].
In the N10, all sublines retained the phenotypic difference between heterozygotes and ISS homozygotes; however, the expected additive effect was not found in the Lore1 congenics [2].
Recently, a large comparative DNA sequencing study of candidate genes located within the four Lore quantitative trait loci (QTLs) associated with the ethanol-induced loss of righting reflex in ILS and ISS mice has identified eight genes that contain coding region differences corresponding to amino acid changes [3].
Recombinant mice were backcrossed to ISS, and progeny carrying the ISCR chromosome were identified and tested to determine whether the ISCR region carried the donor Lore QTL [4].
Evidence that the Lore-1 region specifies ethanol-induced activation in addition to sedative/hypnotic sensitivity to ethanol [5].

References

Differential effects of ethanol on gamma-aminobutyric acid-A receptor-mediated synaptic currents in congenic strains of inbred long and short-sleep mice. Proctor, W.R., Wu, P.H., Bennett, B., Johnson, T.E. Alcohol. Clin. Exp. Res. (2004) [Pubmed]
Reciprocal congenics defining individual quantitative trait Loci for sedative/hypnotic sensitivity to ethanol. Bennett, B., Beeson, M., Gordon, L., Johnson, T.E. Alcohol. Clin. Exp. Res. (2002) [Pubmed]
Fine mapping of polymorphic alcohol-related quantitative trait loci candidate genes using interval-specific congenic recombinant mice. Ehringer, M.A., Thompson, J., Conroy, O., Yang, F., Hink, R., Bennett, B., Johnson, T.E., Sikela, J.M. Alcohol. Clin. Exp. Res. (2002) [Pubmed]
Genetic dissection of quantitative trait loci specifying sedative/hypnotic sensitivity to ethanol: mapping with interval-specific congenic recombinant lines. Bennett, B., Beeson, M., Gordon, L., Carosone-Link, P., Johnson, T.E. Alcohol. Clin. Exp. Res. (2002) [Pubmed]
Evidence that the Lore-1 region specifies ethanol-induced activation in addition to sedative/hypnotic sensitivity to ethanol. Owens, J.C., Bennett, B., Johnson, T.E. Alcohol. Clin. Exp. Res. (2001) [Pubmed]

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