The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Gabrb2  -  gamma-aminobutyric acid (GABA) A receptor,...

Mus musculus

Synonyms: AI834970, C030002O17Rik, C030021G16Rik, GABA(A) receptor subunit beta-2, Gabrab2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Gabrb2


Psychiatry related information on Gabrb2


High impact information on Gabrb2

  • PrP null mice show abnormalities of synaptic neurophysiology, in particular weakened GABAA receptor-mediated fast inhibition and impaired long-term potentiation in the hippocampus [10].
  • Here we show that this tonic conductance is absent in granule cells that lack the alpha6 and delta-subunits of the GABAA receptor [11].
  • In cerebellar granule cells, although the frequency of inhibitory synaptic currents is relatively low, the spillover of synaptically released GABA (gamma-aminobutyric acid) gives rise to a persistent conductance mediated by the GABA A receptor that also modifies the excitability of granule cells [11].
  • In nicotinic acetylcholine receptors (nAChR), as well as glycine, GABAA (gamma-aminobutyric acid), serotonin (5-HT3), and GluCl glutamate receptors, a leucine residue at the approximate midpoint of the M2 transmembrane domain (the 9' position) is conserved across most known subunits [12].
  • These findings indicate that the anxiolytic effect of benzodiazepine drugs is mediated by alpha2 GABAA receptors, which are largely expressed in the limbic system, but not by alpha3 GABAA receptors, which predominate in the reticular activating system [13].

Chemical compound and disease context of Gabrb2


Biological context of Gabrb2


Anatomical context of Gabrb2


Associations of Gabrb2 with chemical compounds


Physical interactions of Gabrb2

  • The gamma 2 subunit and gephyrin are thus interdependent components of the same synaptic complex that is critical for postsynaptic clustering of abundant subtypes of GABAA receptors in vivo [29].
  • To further study the putative gamma-butyrolactone site of the GABAA/chloride channel complex, constrained derivatives of convulsant and anticonvulsant alpha,alpha-disubstituted gamma-butyrolactones (alpha-spirocyclopropyl- and alpha-spirocyclopentyl-gamma-butyrolactones) were synthesized and evaluated biologically [30].
  • Using the selective GABAA receptor agonist isoguvacine it could be demonstrated that the GABAB receptors are functionally coupled to GABAA receptors in the neurons leading to a disinhibitory action of GABAB receptor agonists [31].
  • It is therefore concluded that whilst chlormethiazole effectively antagonises the convulsive behavioural syndrome induced by injection of NMDLA, it does not do so by interacting with the NMDA receptor complex but more probably by its known interaction with the GABAA receptor complex [32].
  • Diazepam binding inhibitor (DBI) is a putative endogenous ligand capable of binding to the central type benzodiazepine (BZD) receptor located on the GABAA receptor and the peripheral type BZD receptor on the mitochondrial outer membrane [33].

Co-localisations of Gabrb2

  • Likewise, the distribution, number and size of GABAA receptor clusters colocalized with gephyrin are similar to wild-type in both juvenile and adult mice [34].
  • Here, we show by double-immunofluorescence staining that dystrophin is extensively colocalized with GABAA receptor subunit clusters in these brain regions [35].

Regulatory relationships of Gabrb2

  • Cerebellar granule-cell-specific GABAA receptors attenuate benzodiazepine-induced ataxia: evidence from alpha 6-subunit-deficient mice [14].
  • Although the BDNF-induced GABAA receptor internalization was sensitive to K252a, it did not become manifest until 5 min after exposure to BDNF [36].
  • A recent in vitro study [Ganguly et al. (2001) Cell, 105, 521-532] showed that KCC2 expression may be under the trophic control of GABAA receptor-mediated transmission [37].
  • We hypothesized that Hcy transduces MVEC remodeling by increasing metalloproteinase activity and shedding beta-1 integrin by inactivating the GABA-A/B receptors, thus behaving as an excitatory neurotransmitter [38].
  • The inhibitory effects of GABA on glucagon secretion by alpha TC6 cells were blocked by the GABAA receptor antagonist bicuculline and were dissociated from the inhibitory effects of glucose [39].

Other interactions of Gabrb2

  • Differential cell surface expression of GABAA receptor alpha1, alpha6, beta2 and beta3 subunits in cultured mouse cerebellar granule cells influence of cAMP-activated signalling [40].
  • We compare the sequence and expression of the beta 1, beta 2 and beta 3 subunits of GABAA receptors in two inbred strains of mice, DBA/2J and C57BL/6J, which differ markedly in seizure susceptibility and in a variety of behaviors related to alcohol [41].
  • This showed that although Sts may cause alterations in GABAA subunit expression, these changes do not result in increased fear reactivity [42].
  • GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions [43].
  • Thus, we have identified an abnormality in the GABAA receptor profile of stg/stg mutant mice that might underpin its irregular phenotype [44].

Analytical, diagnostic and therapeutic context of Gabrb2

  • In the present study, [35S]cRNA probes were used to examine the appearance and distribution of GABAA/BZ beta 1, beta 2, and beta 3 subunit mRNAs in the developing C57BL/6 mouse cerebellum by in situ hybridization [45].
  • In primary embryonic rat neuronal cell cultures, a similar regulation of GABAA receptors by PKA was observed [22].
  • Site-specific mutagenesis of the serine residue phosphorylated by PKA completely eliminated the PKA phosphorylation and modulation of the GABAA receptor [22].
  • Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics [46].
  • GABAA receptors are molecular substrates for the regulation of vigilance, anxiety, muscle tension, epileptogenic activity, and memory functions, and the enhancement of GABAA receptor-mediated fast synaptic inhibition is the basis for the pharmacotherapy of various neurological and psychiatric disorders [46].


  1. Allelic variation in the GABA A receptor gamma2 subunit is associated with genetic susceptibility to ethanol-induced motor incoordination and hypothermia, conditioned taste aversion, and withdrawal in BXD/Ty recombinant inbred mice. Hood, H.M., Buck, K.J. Alcohol. Clin. Exp. Res. (2000) [Pubmed]
  2. Partial restoration of striatal GABAA receptor balance by functional mesencephalic dopaminergic grafts in mice with hereditary parkinsonism. Stasi, K., Mitsacos, A., Giompres, P., Kouvelas, E.D., Triarhou, L.C. Exp. Neurol. (1999) [Pubmed]
  3. Aberrant expression of GABAA receptor subunits in the tottering mouse: an animal model for absence seizures. Tehrani, M.H., Baumgartner, B.J., Liu, S.C., Barnes, E.M. Epilepsy Res. (1997) [Pubmed]
  4. Neurons derived from embryonal carcinoma (P19) cells express multiple GABAA receptor subunits and fully functional GABAA receptors. Reynolds, J.N., Ryan, P.J., Prasad, A., Paterno, G.D. Neurosci. Lett. (1994) [Pubmed]
  5. Genetic analysis of the GABRA1 gene in patients with essential tremor. Deng, H., Xie, W.J., Le, W.D., Huang, M.S., Jankovic, J. Neurosci. Lett. (2006) [Pubmed]
  6. Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues. Crestani, F., Lorez, M., Baer, K., Essrich, C., Benke, D., Laurent, J.P., Belzung, C., Fritschy, J.M., Lüscher, B., Mohler, H. Nat. Neurosci. (1999) [Pubmed]
  7. Maternal behavior regulates benzodiazepine/GABAA receptor subunit expression in brain regions associated with fear in BALB/c and C57BL/6 mice. Caldji, C., Diorio, J., Anisman, H., Meaney, M.J. Neuropsychopharmacology (2004) [Pubmed]
  8. Electroconvulsive shock alters GABAA receptor subunit mRNAs: use of quantitative PCR methodology. Pratt, J.S., Kang, I., Bazan, N.G., Miller, L.G. Brain Res. Bull. (1993) [Pubmed]
  9. Genetic differences in the ethanol sensitivity of GABAA receptors expressed in Xenopus oocytes. Wafford, K.A., Burnett, D.M., Dunwiddie, T.V., Harris, R.A. Science (1990) [Pubmed]
  10. Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein. Whittington, M.A., Sidle, K.C., Gowland, I., Meads, J., Hill, A.F., Palmer, M.S., Jefferys, J.G., Collinge, J. Nat. Genet. (1995) [Pubmed]
  11. Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. Brickley, S.G., Revilla, V., Cull-Candy, S.G., Wisden, W., Farrant, M. Nature (2001) [Pubmed]
  12. Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Labarca, C., Nowak, M.W., Zhang, H., Tang, L., Deshpande, P., Lester, H.A. Nature (1995) [Pubmed]
  13. Molecular and neuronal substrate for the selective attenuation of anxiety. Löw, K., Crestani, F., Keist, R., Benke, D., Brünig, I., Benson, J.A., Fritschy, J.M., Rülicke, T., Bluethmann, H., Möhler, H., Rudolph, U. Science (2000) [Pubmed]
  14. Cerebellar granule-cell-specific GABAA receptors attenuate benzodiazepine-induced ataxia: evidence from alpha 6-subunit-deficient mice. Korpi, E.R., Koikkalainen, P., Vekovischeva, O.Y., Mäkelä, R., Kleinz, R., Uusi-Oukari, M., Wisden, W. Eur. J. Neurosci. (1999) [Pubmed]
  15. Developmental expression of functional GABAA receptors containing the gamma 2 subunit in neurons derived from embryonal carcinoma (P19) cells. Reynolds, J.N., Prasad, A., Gillespie, L.L., Paterno, G.D. Brain Res. Mol. Brain Res. (1996) [Pubmed]
  16. Increase in the Bmax of gamma-aminobutyric acid-A recognition sites in brain regions of mice receiving diazepam. Ferrero, P., Guidotti, A., Costa, E. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  17. Status epilepticus in mice deficient for succinate semialdehyde dehydrogenase: GABAA receptor-mediated mechanisms. Wu, Y., Buzzi, A., Frantseva, M., Velazquez, J.P., Cortez, M., Liu, C., Shen, L., Gibson, K.M., Snead, O.C. Ann. Neurol. (2006) [Pubmed]
  18. Involvement of glycine and GABAA receptors in the pathogenesis of spinal myoclonus: in vitro studies in the isolated neonatal rodent spinal cord. Simon, E.S. Neurology (1995) [Pubmed]
  19. Differential expression of GABAA/benzodiazepine receptor subunit mRNAs and ligand binding sites in mouse cerebellar neurons following in vivo ethanol administration: an autoradiographic analysis. Wu, C.H., Frostholm, A., De Blas, A.L., Rotter, A. J. Neurochem. (1995) [Pubmed]
  20. Gamma-aminobutyric acid type A receptor beta 2 subunit mediates the hypothermic effect of etomidate in mice. Cirone, J., Rosahl, T.W., Reynolds, D.S., Newman, R.J., O'Meara, G.F., Hutson, P.H., Wafford, K.A. Anesthesiology (2004) [Pubmed]
  21. The GABAA receptor alpha 6 subunit gene (Gabra6) is tightly linked to the alpha 1-gamma 2 subunit cluster on mouse chromosome 11. Garrett, K.M., Haque, D., Berry, D., Niekrasz, I., Gan, J., Rotter, A., Seale, T.W. Brain Res. Mol. Brain Res. (1997) [Pubmed]
  22. Functional modulation of GABAA receptors by cAMP-dependent protein phosphorylation. Moss, S.J., Smart, T.G., Blackstone, C.D., Huganir, R.L. Science (1992) [Pubmed]
  23. Synapse formation by hippocampal neurons from agrin-deficient mice. Serpinskaya, A.S., Feng, G., Sanes, J.R., Craig, A.M. Dev. Biol. (1999) [Pubmed]
  24. Deletion of the alpha1 or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs. Blednov, Y.A., Jung, S., Alva, H., Wallace, D., Rosahl, T., Whiting, P.J., Harris, R.A. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  25. Regulation of GABAA receptor function by protein kinase C phosphorylation. Krishek, B.J., Xie, X., Blackstone, C., Huganir, R.L., Moss, S.J., Smart, T.G. Neuron (1994) [Pubmed]
  26. GABAA receptor {alpha}4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Chandra, D., Jia, F., Liang, J., Peng, Z., Suryanarayanan, A., Werner, D.F., Spigelman, I., Houser, C.R., Olsen, R.W., Harrison, N.L., Homanics, G.E. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  27. Uncoupling of GABAA/benzodiazepine receptor alpha 1, beta 2, and gamma 2 subunit mRNA expression in cerebellar Purkinje cells of staggerer mutant mice. Luntz-Leybman, V., Rotter, A., Zdilar, D., Frostholm, A. J. Neurosci. (1995) [Pubmed]
  28. Differential expression of two forms of GABAA receptor gamma 2-subunit in mice. Wang, J.B., Burt, D.R. Brain Res. Bull. (1991) [Pubmed]
  29. Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin. Essrich, C., Lorez, M., Benson, J.A., Fritschy, J.M., Lüscher, B. Nat. Neurosci. (1998) [Pubmed]
  30. Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones. Peterson, E.M., Xu, K., Holland, K.D., McKeon, A.C., Rothman, S.M., Ferrendelli, J.A., Covey, D.F. J. Med. Chem. (1994) [Pubmed]
  31. Role of GABAB receptors in intracellular Ca2+ homeostasis and possible interaction between GABAA and GABAB receptors in regulation of transmitter release in cerebellar granule neurons. Kardos, J., Elster, L., Damgaard, I., Krogsgaard-Larsen, P., Schousboe, A. J. Neurosci. Res. (1994) [Pubmed]
  32. Chlormethiazole antagonises seizures induced by N-methyl-DL-aspartate without interacting with the NMDA receptor complex. Cross, A.J., Snape, M.F., Green, A.R. Psychopharmacology (Berl.) (1993) [Pubmed]
  33. Diazepam binding inhibitor (DBI) reduces testosterone and estradiol levels in vivo. Dong, E., Matsumoto, K., Watanabe, H. Life Sci. (2002) [Pubmed]
  34. Rescue of gamma2 subunit-deficient mice by transgenic overexpression of the GABAA receptor gamma2S or gamma2L subunit isoforms. Baer, K., Essrich, C., Balsiger, S., Wick, M.J., Harris, R.A., Fritschy, J.M., Lüscher, B. Eur. J. Neurosci. (2000) [Pubmed]
  35. Short communication: altered synaptic clustering of GABAA receptors in mice lacking dystrophin (mdx mice). Knuesel, I., Mastrocola, M., Zuellig, R.A., Bornhauser, B., Schaub, M.C., Fritschy, J.M. Eur. J. Neurosci. (1999) [Pubmed]
  36. Brain-derived neurotrophic factor attenuates mouse cerebellar granule cell GABA(A) receptor-mediated responses via postsynaptic mechanisms. Cheng, Q., Yeh, H.H. J. Physiol. (Lond.) (2003) [Pubmed]
  37. Developmental up-regulation of KCC2 in the absence of GABAergic and glutamatergic transmission. Ludwig, A., Li, H., Saarma, M., Kaila, K., Rivera, C. Eur. J. Neurosci. (2003) [Pubmed]
  38. GABA receptors ameliorate Hcy-mediated integrin shedding and constrictive collagen remodeling in microvascular endothelial cells. Shastry, S., Tyagi, N., Moshal, K.S., Lominadze, D., Hayden, M.R., Tyagi, S.C. Cell Biochem. Biophys. (2006) [Pubmed]
  39. Glucose modulates gamma-aminobutyric acid release from the pancreatic beta TC6 cell line. Gaskins, H.R., Baldeón, M.E., Selassie, L., Beverly, J.L. J. Biol. Chem. (1995) [Pubmed]
  40. Differential cell surface expression of GABAA receptor alpha1, alpha6, beta2 and beta3 subunits in cultured mouse cerebellar granule cells influence of cAMP-activated signalling. Ives, J.H., Drewery, D.L., Thompson, C.L. J. Neurochem. (2002) [Pubmed]
  41. GABAA receptor beta 1, beta 2, and beta 3 subunits: comparisons in DBA/2J and C57BL/6J mice. Kamatchi, G.L., Kofuji, P., Wang, J.B., Fernando, J.C., Liu, Z., Mathura, J.R., Burt, D.R. Biochim. Biophys. Acta (1995) [Pubmed]
  42. Effects on fear reactivity in XO mice are due to haploinsufficiency of a non-PAR X gene: implications for emotional function in Turner's syndrome. Isles, A.R., Davies, W., Burrmann, D., Burgoyne, P.S., Wilkinson, L.S. Hum. Mol. Genet. (2004) [Pubmed]
  43. GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions. O'Hara, B.F., Andretic, R., Heller, H.C., Carter, D.B., Kilduff, T.S. Brain Res. Mol. Brain Res. (1995) [Pubmed]
  44. Decreased expression of GABAA receptor alpha6 and beta3 subunits in stargazer mutant mice: a possible role for brain-derived neurotrophic factor in the regulation of cerebellar GABAA receptor expression? Thompson, C.L., Tehrani, M.H., Barnes, E.M., Stephenson, F.A. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  45. Differential expression of GABAA/benzodiazepine receptor beta 1, beta 2, and beta 3 subunit mRNAs in the developing mouse cerebellum. Zdilar, D., Luntz-Leybman, V., Frostholm, A., Rotter, A. J. Comp. Neurol. (1992) [Pubmed]
  46. Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Rudolph, U., Möhler, H. Annu. Rev. Pharmacol. Toxicol. (2004) [Pubmed]
WikiGenes - Universities