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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ACOT2  -  acyl-CoA thioesterase 2

Homo sapiens

Synonyms: Acyl-CoA thioesterase 2, Acyl-coenzyme A thioester hydrolase 2a, Acyl-coenzyme A thioesterase 2, mitochondrial, CTE-IA, CTE-Ia, ...
 
 
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High impact information on ACOT2

  • PTE2 was targeted to peroxisomes and recombinant PTE2 showed intrinsic acyl-CoA thioesterase activity with a pH optimum of 8 [1].
  • The PTE2 gene product is highly similar to the rat cytosolic and mitochondrial thioesterases, CTE1 and MTE1, respectively, and terminates in a tripeptide sequence, serine-lysine-valine(COOH), that resembles the consensus sequence for type-1 peroxisomal targeting signals [1].
  • We therefore set out to characterize the human genes, and we show here that the human ACOT4 protein catalyzes the activities of three mouse peroxisomal ACOTs (ACOT3, 4, and 5), being active on succinyl-CoA and medium to long chain acyl-CoAs, while ACOT1 and ACOT2 carry out similar functions to the corresponding mouse genes [2].
 

Biological context of ACOT2

 

Associations of ACOT2 with chemical compounds

References

  1. Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. Jones, J.M., Gould, S.J. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  2. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. Hunt, M.C., Rautanen, A., Westin, M.A., Svensson, L.T., Alexson, S.E. FASEB J. (2006) [Pubmed]
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