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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

COPS6  -  COP9 signalosome subunit 6

Homo sapiens

Synonyms: COP9 signalosome complex subunit 6, CSN6, HVIP, JAB1-containing signalosome subunit 6, MOV34 homolog, ...
 
 
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Disease relevance of COPS6

  • These results support the view that hVIP is a member of the complex array of nucleocytoplasmic shuttling proteins that are regulated by HIV infection and glucocorticoids [1].
  • We conclude that hVIP/MOV34 is involved in the regulation of the cell cycle and a likely cellular cofactor for HIV-1 Vpr [2].
 

High impact information on COPS6

  • In fact, we also observed that dexamethasone moves hVIP into the nucleus and that glucocorticoid antagonists inhibit this effect [1].
  • By using the yeast two-hybrid system, Lys-tRNA synthetase (LysRS) was identified as a Vpr-interacting protein [3].
  • The results of transient expression experiments in COS7 cells confirmed the interaction of Int-6 with Rpt4, CSN3 and CSN6, but also showed that Int-6 is able to bind another subunit of the CSN: CSN7a [4].
  • By performing a two-hybrid screen with Int-6 as bait, we have isolated subunits belonging to all three complexes, namely eIF3-p110, Rpt4, CSN3 and CSN6 [4].
 

Biological context of COPS6

  • We observe an association between the induction of cell cycle arrest at the G2/M phase border by Vpr and a change in the subcellular localization of hVIP/MOV34 from a nuclear to a perinuclear localization [2].
 

Other interactions of COPS6

  • Carboxyl terminus of hVIP/mov34 is critical for HIV-1-Vpr interaction and glucocorticoid-mediated signaling [1].
 

Analytical, diagnostic and therapeutic context of COPS6

References

  1. Carboxyl terminus of hVIP/mov34 is critical for HIV-1-Vpr interaction and glucocorticoid-mediated signaling. Ramanathan, M.P., Curley, E., Su, M., Chambers, J.A., Weiner, D.B. J. Biol. Chem. (2002) [Pubmed]
  2. HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle. Mahalingam, S., Ayyavoo, V., Patel, M., Kieber-Emmons, T., Kao, G.D., Muschel, R.J., Weiner, D.B. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA synthetase: implications for priming of HIV-1 reverse transcription. Stark, L.A., Hay, R.T. J. Virol. (1998) [Pubmed]
  4. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. Hoareau Alves, K., Bochard, V., Réty, S., Jalinot, P. FEBS Lett. (2002) [Pubmed]
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