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Gene Review

COPS6  -  COP9 signalosome subunit 6

Homo sapiens

Synonyms: COP9 signalosome complex subunit 6, CSN6, HVIP, JAB1-containing signalosome subunit 6, MOV34 homolog, ...
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Disease relevance of COPS6

  • These results support the view that hVIP is a member of the complex array of nucleocytoplasmic shuttling proteins that are regulated by HIV infection and glucocorticoids [1].
  • We conclude that hVIP/MOV34 is involved in the regulation of the cell cycle and a likely cellular cofactor for HIV-1 Vpr [2].

High impact information on COPS6

  • In fact, we also observed that dexamethasone moves hVIP into the nucleus and that glucocorticoid antagonists inhibit this effect [1].
  • By using the yeast two-hybrid system, Lys-tRNA synthetase (LysRS) was identified as a Vpr-interacting protein [3].
  • The results of transient expression experiments in COS7 cells confirmed the interaction of Int-6 with Rpt4, CSN3 and CSN6, but also showed that Int-6 is able to bind another subunit of the CSN: CSN7a [4].
  • By performing a two-hybrid screen with Int-6 as bait, we have isolated subunits belonging to all three complexes, namely eIF3-p110, Rpt4, CSN3 and CSN6 [4].

Biological context of COPS6

  • We observe an association between the induction of cell cycle arrest at the G2/M phase border by Vpr and a change in the subcellular localization of hVIP/MOV34 from a nuclear to a perinuclear localization [2].

Other interactions of COPS6

  • Carboxyl terminus of hVIP/mov34 is critical for HIV-1-Vpr interaction and glucocorticoid-mediated signaling [1].

Analytical, diagnostic and therapeutic context of COPS6


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