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Gene Review:

Gv1 - Gross virus antigen 1

Mus musculus

Synonyms: Gv-1

Stockert, E. et al., Oliver, P.L. et al.

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Disease relevance of Gv1

Genetic analysis of Gv1, a gene controlling transcription of endogenous murine polytropic proviruses [1].

High impact information on Gv1

This GIX-gp70 molecule is found on the thymocytes of some (GIX+) strains of mice, where its expression is controlled by two mendelian genes, Gv-1 and Gv-2 [2].
Previous recombination data involving the prototype GIX+ strain 129 indicated that the H-2 (chromosome 17) and Gv-1 loci are linked, at a distance of 36 units from one another [2].
Other previous recombination data, involving the GIX+ strain AKR, had indicated that the Gpd-1 (chromosome 4) and Gv-1 loci are linked at a distance of 19 units from one another [2].
Gv1 is a genetic locus that coordinately regulates the expression of multiple murine leukemia virus-related endogenous proviral sequences [1].

Biological context of Gv1

A combination of genetic techniques were used to map Gv1; these analyses demonstrate that Gv1 lies approximately 37 centimorgans from the centromeric end of mouse chromosome 13 [1].

Analytical, diagnostic and therapeutic context of Gv1

A quantitative nuclease protection assay for typing Gv1 inheritance has been developed [1].

References

Genetic analysis of Gv1, a gene controlling transcription of endogenous murine polytropic proviruses. Oliver, P.L., Stoye, J.P. J. Virol. (1999) [Pubmed]
Heredity of the GIX thymocyte antigen associated with murine leukemia virus: segregation data simulating genetic linkage. Stockert, E., Boyse, E.A., Sato, H., Itakura, K. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]

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