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Gene Review:

Fvis1 - Friend virus integration site 1

Mus musculus

Synonyms: Fis-1, Fis1

Silver, J. et al., Silver, J. et al., Lammie, G.A. et al.

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Disease relevance of Fvis1

Therefore, Fis-1 appears to be a novel sequence implicated in both lymphoid and myeloid leukemias induced by F-MuLV [1].
Gene mapping experiments show that Fis-1, a preferred integration region for Friend murine leukemia virus in hematopoietic neoplasms, is extremely closely linked to Int-2, a preferred integration region for mouse mammary tumor virus in mammary carcinomas [2].

High impact information on Fvis1

As there is no intervening CpG island, proviral insertions at Fis-1 could influence the expression of Cyl-1 and we describe two virally induced tumours in which this appears to be the case [3].
Using mouse-Chinese hamster somatic cell hybrids, we mapped this common integration region, designated Fis-1, to mouse chromosome 7 [1].

References

Common proviral integration region on mouse chromosome 7 in lymphomas and myelogenous leukemias induced by Friend murine leukemia virus. Silver, J., Kozak, C. J. Virol. (1986) [Pubmed]
A preferred region for integration of Friend murine leukemia virus in hematopoietic neoplasms is closely linked to the Int-2 oncogene. Silver, J., Buckler, C.E. J. Virol. (1986) [Pubmed]
Proviral insertions near cyclin D1 in mouse lymphomas: a parallel for BCL1 translocations in human B-cell neoplasms. Lammie, G.A., Smith, R., Silver, J., Brookes, S., Dickson, C., Peters, G. Oncogene (1992) [Pubmed]

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