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Gene Review:

Tir3 - trypanosome infection response 3

Mus musculus

Iraqi, F. et al., Clapcott, S.J. et al., Kemp, S.J. et al.

Kemp, Iraqi, Darvasi, Soller, Teale,

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Disease relevance of Tir3

Mapping in the AILs also resolved the Tir3 locus into three trypanosomiasis resistance QTLs, revealing a degree of complexity not evident in extensive studies at the F(2) level [1].

High impact information on Tir3

We propose that they be designated Tir1, Tir2 and Tir3 [2].
Three loci, Tir1, Tir2, and Tir3, were identified and mapped to mouse Chromosomes (Chrs) 17, 5, and 1 respectively, with confidence intervals (CIs) in the range 10-40 cM [1].

Biological context of Tir3

The difference in survival time between the relatively resistant C57BL/6 J and more susceptible BALB/c inbred strains has been attributed to three quantitative trait loci (QTLs), Tir1, Tir2 and Tir3 [3].

Other interactions of Tir3

Here we report fine mapping of Tir1, Tir2, and Tir3 in G6 populations of two independent murine AILs created by crossing the C57BL/6J strain with the A/J and BALB/cJ strains, respectively [1].

References

Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines. Iraqi, F., Clapcott, S.J., Kumari, P., Haley, C.S., Kemp, S.J., Teale, A.J. Mamm. Genome (2000) [Pubmed]
Localization of genes controlling resistance to trypanosomiasis in mice. Kemp, S.J., Iraqi, F., Darvasi, A., Soller, M., Teale, A.J. Nat. Genet. (1997) [Pubmed]
Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice. Clapcott, S.J., Teale, A.J., Kemp, S.J. Parasite Immunol. (2000) [Pubmed]

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