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Gene Review

Tir1  -  trypanosome infection response 1

Mus musculus

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High impact information on Tir1

  • The TNF-alpha gene on mouse chromosome MMU17 is among the candidates for the trypanosomosis resistance QTL Tir1 [1].
  • Here we report fine mapping of Tir1, Tir2, and Tir3 in G6 populations of two independent murine AILs created by crossing the C57BL/6J strain with the A/J and BALB/cJ strains, respectively [2].
  • Genotyping with markers at the three QTLs controlling susceptibility revealed that the difference in survival time was consistent with genomic imprinting of the QTL of largest effect, Tir1 [3].
  • The heat shock protein (HSP) 70.1 gene lies on mouse chromosome 17 among the candidates for Tir1, the major quantitative trait locus associated with response to Trypanosoma congolense infection [4].

Biological context of Tir1

  • The difference in survival time between the relatively resistant C57BL/6 J and more susceptible BALB/c inbred strains has been attributed to three quantitative trait loci (QTLs), Tir1, Tir2 and Tir3 [3].


  1. Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection. Iraqi, F., Sekikawa, K., Rowlands, J., Teale, A. Parasite Immunol. (2001) [Pubmed]
  2. Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines. Iraqi, F., Clapcott, S.J., Kumari, P., Haley, C.S., Kemp, S.J., Teale, A.J. Mamm. Genome (2000) [Pubmed]
  3. Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice. Clapcott, S.J., Teale, A.J., Kemp, S.J. Parasite Immunol. (2000) [Pubmed]
  4. Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection. Nakamura, Y., Naessens, J., Takata, M., Taniguchi, T., Sekikawa, K., Gibson, J., Iraqi, F. Parasitol. Res. (2003) [Pubmed]
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