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Gene Review:

Tir1 - trypanosome infection response 1

Mus musculus

Clapcott, S.J. et al., Iraqi, F. et al., Nakamura, Y. et al., Iraqi, F. et al.

Nakamura, Naessens, Takata, Taniguchi, Sekikawa, Gibson, Iraqi,

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High impact information on Tir1

The TNF-alpha gene on mouse chromosome MMU17 is among the candidates for the trypanosomosis resistance QTL Tir1 [1].
Here we report fine mapping of Tir1, Tir2, and Tir3 in G6 populations of two independent murine AILs created by crossing the C57BL/6J strain with the A/J and BALB/cJ strains, respectively [2].
Genotyping with markers at the three QTLs controlling susceptibility revealed that the difference in survival time was consistent with genomic imprinting of the QTL of largest effect, Tir1 [3].
The heat shock protein (HSP) 70.1 gene lies on mouse chromosome 17 among the candidates for Tir1, the major quantitative trait locus associated with response to Trypanosoma congolense infection [4].

Biological context of Tir1

The difference in survival time between the relatively resistant C57BL/6 J and more susceptible BALB/c inbred strains has been attributed to three quantitative trait loci (QTLs), Tir1, Tir2 and Tir3 [3].

References

Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection. Iraqi, F., Sekikawa, K., Rowlands, J., Teale, A. Parasite Immunol. (2001) [Pubmed]
Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines. Iraqi, F., Clapcott, S.J., Kumari, P., Haley, C.S., Kemp, S.J., Teale, A.J. Mamm. Genome (2000) [Pubmed]
Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice. Clapcott, S.J., Teale, A.J., Kemp, S.J. Parasite Immunol. (2000) [Pubmed]
Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection. Nakamura, Y., Naessens, J., Takata, M., Taniguchi, T., Sekikawa, K., Gibson, J., Iraqi, F. Parasitol. Res. (2003) [Pubmed]

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