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Gene Review

cyaB2  -  adenylate cyclase

Nostoc sp. PCC 7120

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Disease relevance of cyaB2

  • The tandem GAF domains from the cyanobacterium Anabaena PCC7120 cyaB2 adenylyl cyclase form an antiparallel dimer with cAMP bound to all four binding sites. cAMP binding causes highly cooperative allosteric enzyme activation (>500-fold; EC(50) = 1 microM; Hill coefficient >2.0) [1].

High impact information on cyaB2

  • The cyaB2 GAF domain NKFDE motifs contain inserts of 14 (GAF-A) and 19 (GAF-B) amino acids not present in PDE2 or cyaB1 [1].


  1. The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites. Bruder, S., Linder, J.U., Martinez, S.E., Zheng, N., Beavo, J.A., Schultz, J.E. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
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