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Gene Review:

cyaB1 - adenylate cyclase

Nostoc sp. PCC 7120

Kanacher, T. et al., Bruder, S. et al.

Bruder, Linder, Martinez, Zheng, Beavo, Schultz,

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Disease relevance of cyaB1

The gene cyaB1 from the cyanobacterium Anabaena sp. PCC 7120 codes for a protein consisting of two N-terminal GAF domains (GAF-A and GAF-B), a PAS domain and a class III adenylyl cyclase catalytic domain [1].
In cyanobacteria, cyaB1 may act as a cAMP switch to stabilize committed developmental decisions [1].

High impact information on cyaB1

The cyaB2 GAF domain NKFDE motifs contain inserts of 14 (GAF-A) and 19 (GAF-B) amino acids not present in PDE2 or cyaB1 [2].

References

A GAF-domain-regulated adenylyl cyclase from Anabaena is a self-activating cAMP switch. Kanacher, T., Schultz, A., Linder, J.U., Schultz, J.E. EMBO J. (2002) [Pubmed]
The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites. Bruder, S., Linder, J.U., Martinez, S.E., Zheng, N., Beavo, J.A., Schultz, J.E. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]

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