Disease relevance of CHD3

• Furthermore, hZFH has 68.5% identity to a human Mi-2 autoantigen to which autoantibodies are produced by a subgroup of patients affected by dermatomyositis [1].
• An expanding phenotype of the ATRX gene (a RAD54 homologue encoding a putative zinc-finger helicase) has been demonstrated as a result of the association of single mutations with specific X-linked mental retardation syndromes [2].

High impact information on CHD3

• Both NAB proteins can bind either CHD3 or CHD4, indicating that the interaction is conserved among these two protein families [3].
• Complex cII (15 S) contained >/=15 proteins, including CHD3/4 (Mi-2), Mta-L1, RbAp48/46, and MBD3, characteristic of vertebrate nucleosome-remodeling complexes [4].
• Mapping showed that CGI-55 interacts with CHD-3 via two regions at its N- and C-terminals [5].
• Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3 [5].
• Determination of the genomic structure of the XNP/ATRX gene encoding a potential zinc finger helicase [6].

Biological context of CHD3

• The deduced protein, designated hZFH (human zinc-finger helicase), contains the seven domains conserved among the helicase superfamily II and four potential zinc-fingers motifs [1].

Associations of CHD3 with chemical compounds

• For isotopomers containing CH3D and CHD3, two K = 0 components were recorded, correlating to the j(k) = 0(0) and 1(1) rotational levels of free methane (k corresponds to the projection of j onto the C3 axis of CH3D and CHD3) [7].

Other interactions of CHD3

• The interaction of CGI-55 and CHD-3 could be confirmed in vitro and in vivo by co-immunoprecipitations from Sf9 insect cells [5].
• By exploiting different combinations of OH/OD + CH4/CD4/CHD3, a total of eight isotopically variant reactions are examined to decipher the dynamical consequence of both primary and secondary isotope effects [8].

Analytical, diagnostic and therapeutic context of CHD3

• Northern-blot analyses have revealed several hZFH mRNAs with quantitative differences in various human tissues [1].
• We also report the chromosomal localization of gene hZFH to locus 17p13-17p12 by in situ hybridization [1].

References