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Gene Review

SERBP1  -  SERPINE1 mRNA binding protein 1

Homo sapiens

Synonyms: CGI-55, CHD3IP, DKFZP564M2423, HABP4L, PAI-RBP1, ...
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High impact information on SERBP1


Biological context of SERBP1

  • The human protein CGI-55 has been described as a chromo-helicase-DNA-binding domain protein (CHD)-3 interacting protein and was also found to interact with the 3'-region of the plasminogen activator inhibitor (PAI)-1 mRNA [4].
  • A mapping study of the CGI-55 binding site for these proteins revealed three distinct patterns of interaction [4].
  • Using immunofluorescence experiments we observed that treatment of HeLa cells with an inhibitor of methylation, adenosine-2',3'-dialdehyde (Adox), led to a reduction in the cytoplasmic immunostaining of Ki-1/57, whereas its paralog CGI-55 was partially redistributed from the nucleus to the cytoplasm upon Adox treatment [5].

Associations of SERBP1 with chemical compounds

  • We found that Ki-1/57 and its putative paralog CGI-55 have two conserved Gly/Arg-rich motif clusters (RGG/RXR box, where X is any amino acid) that may be substrates for arginine-methylation by PRMT1 [5].

Other interactions of SERBP1


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