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Gene Review

Iglc2  -  immunoglobulin lambda constant 2

Mus musculus

Synonyms: Ig lambda-2 chain C region, Igl-C2
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Disease relevance of Igl-C2


High impact information on Igl-C2

  • Using a pCRI plasmid containing an enzymatically synthesized, full-length DNA transcript of immunoglobulin lambda chain mRNA as the hybridization probe in the Southern gel blotting experiments (Southern, 1975), we identified three DNA fragments of 8.6, 4.8 and 3.5 kb in Eco RI-digested total DNA from BALB/c mouse embryos [2].
  • Two pseudogenes among three rat immunoglobulin lambda chain genes [3].


  1. Post-translational fate of variant MOPC 315 lambda chains in Xenopus oocytes and mouse myeloma cells. Valle, G., Besley, J., Williamson, A.R., Mosmann, T.R., Colman, A. Eur. J. Biochem. (1983) [Pubmed]
  2. A complete immunoglobulin gene is created by somatic recombination. Brack, C., Hirama, M., Lenhard-Schuller, R., Tonegawa, S. Cell (1978) [Pubmed]
  3. Two pseudogenes among three rat immunoglobulin lambda chain genes. Frank, M.B., Gutman, G.A. Mol. Immunol. (1988) [Pubmed]
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