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Gene Review:

Iglc2 - immunoglobulin lambda constant 2

Mus musculus

Synonyms: Ig lambda-2 chain C region, Igl-C2

Brack, C. et al., Valle, G. et al., Frank, M.B. et al.

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Disease relevance of Igl-C2

The post-translational fates of three immunoglobulin lambda chain variants of MOPC 315 were investigated in mouse plasmacytoma cell lines and in mRNA-microinjected Xenopus oocytes [1].

High impact information on Igl-C2

Using a pCRI plasmid containing an enzymatically synthesized, full-length DNA transcript of immunoglobulin lambda chain mRNA as the hybridization probe in the Southern gel blotting experiments (Southern, 1975), we identified three DNA fragments of 8.6, 4.8 and 3.5 kb in Eco RI-digested total DNA from BALB/c mouse embryos [2].
Two pseudogenes among three rat immunoglobulin lambda chain genes [3].

References

Post-translational fate of variant MOPC 315 lambda chains in Xenopus oocytes and mouse myeloma cells. Valle, G., Besley, J., Williamson, A.R., Mosmann, T.R., Colman, A. Eur. J. Biochem. (1983) [Pubmed]
A complete immunoglobulin gene is created by somatic recombination. Brack, C., Hirama, M., Lenhard-Schuller, R., Tonegawa, S. Cell (1978) [Pubmed]
Two pseudogenes among three rat immunoglobulin lambda chain genes. Frank, M.B., Gutman, G.A. Mol. Immunol. (1988) [Pubmed]

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