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Gene Review: 

EP0049  -  traA protein

Enterococcus faecalis

 
 
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Disease relevance of EP0049

  • Regulation of the pAD1 sex pheromone response of Enterococcus faecalis by direct interaction between the cAD1 peptide mating signal and the negatively regulating, DNA-binding TraA protein [1].
 

High impact information on EP0049

  • The TraA protein (660 amino acids) and a C-terminally truncated version of the TraA protein (293 amino acids) were purified as fusions with glutathione S-transferase. oriT cleavage activity of both TraA proteins was demonstrated in vitro on supercoiled plasmid pVA2241 DNA containing oriT(pIP501) [2].
  • The transcriptional start site of the tra mRNA was mapped at 110 bp upstream from the predicted TTG start codon of the first gene of the operon, the traA relaxase [2].
 

Biological context of EP0049

  • Pheromone-induced conjugal transfer of the hemolysin-bacteriocin plasmid pAD1 of Enterococcus faecalis is regulated by a cluster of determinants designated traA, traB, and regions C and E. The E region is believed to include a positive regulator that controls many structural genes related to conjugation [3].

References

  1. Regulation of the pAD1 sex pheromone response of Enterococcus faecalis by direct interaction between the cAD1 peptide mating signal and the negatively regulating, DNA-binding TraA protein. Fujimoto, S., Clewell, D.B. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. The tra region of the conjugative plasmid pIP501 is organized in an operon with the first gene encoding the relaxase. Kurenbach, B., Grothe, D., Farías, M.E., Szewzyk, U., Grohmann, E. J. Bacteriol. (2002) [Pubmed]
  3. Regulation of the pAD1 sex pheromone response in Enterococcus faecalis: effects of host strain and traA, traB, and C region mutants on expression of an E region pheromone-inducible lacZ fusion. Weaver, K.E., Clewell, D.B. J. Bacteriol. (1990) [Pubmed]
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