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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PWP1  -  PWP1 homolog (S. cerevisiae)

Homo sapiens

Synonyms: IEF-SSP-9502, Keratinocyte protein IEF SSP 9502, Periodic tryptophan protein 1 homolog
 
 
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High impact information on PWP1

  • Database searching indicated that IEF SSP 9502 is a putative human homologue of the Saccharomyces cerevisiae periodic Trp protein, PWP1, a polypeptide that may play a regulatory role in cell growth and/or transcription [1].
  • In addition, results from the N-terminal microsequence of this protein allow us to define PWP-1 as a novel cell wall protein [2].
 

Analytical, diagnostic and therapeutic context of PWP1

  • Western blots, using a polyclonal serum generated against purified PWP-1 from P. atlanticus, revealed that this protein is expressed by all walled developmental stages of this protozoon [2].
  • By means of immunogold electron microscopy, labelling for PWP-1 was strong and specifically associated with the cell wall [2].

References

  1. Cloning of a cDNA encoding a novel human nuclear phosphoprotein belonging to the WD-40 family. Honoré, B., Leffers, H., Madsen, P., Celis, J.E. Gene (1994) [Pubmed]
  2. Characterization and immunolocalization of a main proteinaceous component of the cell wall of the protozoan parasite Perkinsus atlanticus. Montes, J.F., Durfort, M., Lladó, A., García-Valero, J. Parasitology (2002) [Pubmed]
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