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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PWP1  -  Pwp1p

Saccharomyces cerevisiae S288c

Synonyms: L8167.10, Periodic tryptophan protein 1, YLR196W
 
 
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Disease relevance of PWP1

  • The transcript encoding endonuclein, the human homolog of yeast PWP1, was previously found up-regulated in pancreatic cancer tissue [1].
 

High impact information on PWP1

  • Comparative analysis of the beta transducin family with identification of several new members including PWP1, a nonessential gene of Saccharomyces cerevisiae that is divergently transcribed from NMT1 [2].
  • As an example, the highly conserved mouse gene PWP1 is widely expressed across different tissues but is co-expressed with many RNA-processing genes; we show that the uncharacterized yeast homolog of PWP1 is required for rRNA biogenesis [3].
 

Analytical, diagnostic and therapeutic context of PWP1

  • We obtained in vivo evidence, by a chromatin immunoprecipitation assay, that one of the candidate proteins, Pwp1p, associates with the 25S ribosomal DNA (rDNA) chromatin in an H4-tail-dependent manner [4].

References

  1. Endonuclein is a cell cycle regulated WD-repeat protein that is up-regulated in adenocarcinoma of the pancreas. Honoré, B., Baandrup, U., Nielsen, S., Vorum, H. Oncogene (2002) [Pubmed]
  2. Comparative analysis of the beta transducin family with identification of several new members including PWP1, a nonessential gene of Saccharomyces cerevisiae that is divergently transcribed from NMT1. Duronio, R.J., Gordon, J.I., Boguski, M.S. Proteins (1992) [Pubmed]
  3. The functional landscape of mouse gene expression. Zhang, W., Morris, Q.D., Chang, R., Shai, O., Bakowski, M.A., Mitsakakis, N., Mohammad, N., Robinson, M.D., Zirngibl, R., Somogyi, E., Laurin, N., Eftekharpour, E., Sat, E., Grigull, J., Pan, Q., Peng, W.T., Krogan, N., Greenblatt, J., Fehlings, M., van der Kooy, D., Aubin, J., Bruneau, B.G., Rossant, J., Blencowe, B.J., Frey, B.J., Hughes, T.R. J. Biol. (2004) [Pubmed]
  4. The WD40-repeat protein Pwp1p associates in vivo with 25S ribosomal chromatin in a histone H4 tail-dependent manner. Suka, N., Nakashima, E., Shinmyozu, K., Hidaka, M., Jingami, H. Nucleic Acids Res. (2006) [Pubmed]
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